60115-34-6

Basic information

• Product Name: S-(2-aminophenyl)-L-cysteine
• Synonyms: S-(2-aminophenyl)-L-cysteine
• CAS NO: 60115-34-6
• Molecular Weight: 212.272
• Mol File: 60115-34-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: S-(2-aminophenyl)-L-cysteine(CAS DataBase Reference)
• NIST Chemistry Reference: S-(2-aminophenyl)-L-cysteine(60115-34-6)
• EPA Substance Registry System: S-(2-aminophenyl)-L-cysteine(60115-34-6)

Safety Data

• Hazardous Substances Data: 60115-34-6(Hazardous Substances Data)

Upstream product

• 5147-00-2 O-acetyl-L-serine 
• 137-07-5 2-amino-benzenethiol 
• 407-41-0 L-phosphoserine 
• 49732-37-8 2-Nitrobenzenediazonium Bisulfate 
• 1493-27-2 ortho-nitrofluorobenzene 
• 60115-45-9 S-(o-nitrophenyl)-L-cysteine 

Relevant articles and documents

Expanding the Structural Diversity of Protein Building Blocks with Noncanonical Amino Acids Biosynthesized from Aromatic Thiols

Incorporation of structurally novel noncanonical amino acids (ncAAs) into proteins is valuable for both scientific and biomedical applications. To expand the structural diversity of available ncAAs and to reduce the burden of chemically synthesizing them, we have developed a general and simple biosynthetic method for genetically encoding novel ncAAs into recombinant proteins by feeding cells with economical commercially available or synthetically accessible aromatic thiols. We demonstrate that nearly 50 ncAAs with a diverse array of structures can be biosynthesized from these simple small-molecule precursors by hijacking the cysteine biosynthetic enzymes, and the resulting ncAAs can subsequently be incorporated into proteins via an expanded genetic code. Moreover, we demonstrate that bioorthogonal reactive groups such as aromatic azides and aromatic ketones can be incorporated into green fluorescent protein or a therapeutic antibody with high yields, allowing for subsequent chemical conjugation.

Unnatural amino acid synthesis by thermostable O-phospho-L-serine sulfhydrylase from hyperthermophilic archaeon Aeropyrum pernix K1

O-Acetyl-L-serine sulfhydrylase (OASS) from plants and bacteria synthesizes cysteine and unnatural amino acids that are important building blocks for active pharmaceuticals and agrochemicals. A thermostable O-phospho-L-serine sulfhydrylase from hyperthermophilic archaeon Aeropyrum pernix K1 (OPSSAp) exhibits a function similar to OASS. In the present study, we examined the synthesis of various unnatural amino acids using OPSSAp and demonstrated OPSSAp could efficiently synthesize various sulfur-containing amino acids. OPSSAp would be useful for industrial production of biologically important unnatural amino acids.