60116-77-0

Usage

Uses

Used in Pharmaceutical Research and Organic Synthesis:
2-(TERT-BUTYLTHIO)ETHYLAMINE HYDROCHLORIDE is used as a reagent for its role in the synthesis of pharmaceutical drugs, contributing to the development of new medications.
Used in Antiviral Applications:
In the field of virology, 2-(TERT-BUTYLTHIO)ETHYLAMINE HYDROCHLORIDE is used as an antiviral agent, leveraging its reported antiviral activities to combat viral infections.
Used in Anticancer Applications:
2-(TERT-BUTYLTHIO)ETHYLAMINE HYDROCHLORIDE is used as an anticancer agent, where its potential to exhibit anticancer activities is explored for the treatment of various types of cancer.
Used in Chemical Manufacturing:
In the chemical manufacturing industry, 2-(TERT-BUTYLTHIO)ETHYLAMINE HYDROCHLORIDE is used as an intermediate in the production of various chemical compounds, taking advantage of its reactivity and properties in synthesis processes.

InChI:InChI=1/C6H15NS.ClH/c1-6(2,3)8-5-4-7;/h4-5,7H2,1-3H3;1H

Upstream product

• 156-57-0 2-mercaptoethylamine hydrochloride 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 1361456-17-8 C₆H₅-C{NH(CH₂)2StBu}=NC₆H₅ 

Relevant academic research and scientific papers

A synthetic pathway to Cys-Xxx-Cys (N2S2) analogue ligands: An improved synthesis of HSCH2CH2C(O)NHCH 2C(O)NHCH2CH2SH

Herein, two improved synthetic pathways to biologically relevant Cys-Xxx-Cys analogue ligands used in conjunction with metals as metalloenzyme models (Ni for carbon monoxide dehydrogenase/acetyl-CoA synthase A-cluster; Co and Fe for nitrile hydratase) are reported. Copyright Taylor & Francis Group, LLC.

Metal-chelating inhibitors of a zinc finger protein HIV-EP1. Remarkable potentiation of inhibitory activity by introduction of SH groups

HIV-EP1 is a C2H2 type zinc finger protein which binds to DNA κB site present in the long terminal repeat of HIV provirus. Previously we have reported zinc chelators having histidine-pyridine-histidine skeleton and were successful in inhibiting the DNA binding of HIV-EP1 by removing zinc from the zinc finger domain. Aiming at the potentiation of the inhibitory activity of our previous zinc chelators, herein synthesized were novel chelators comprising pyridine and aminoalkanethiol. These showed marked inhibitory activity on the DNA binding of HIV-EP1. In particular, one of them having a bis(2-mercaptoethyl)amino side chain showed inhibitory activity (IC50, ~4 μM) 10 times stronger than that of the strongest inhibitor that we reported previously. It appeared that these inhibited the DNA binding of HIV-EP1 by a mechanism distinct from that of the previous histidine-based inhibitors.