601463-55-2Relevant academic research and scientific papers
Synthesis and biological profile of new 1,2,3,4-tetrahydroisoquinolines as selective carbonic anhydrase inhibitors
Gitto, Rosaria,Damiano, Francesca Maria,De Luca, Laura,Ferro, Stefania,Vullo, Daniela,Supuran, Claudiu T.,Chimirri, Alba
, p. 7003 - 7007 (2012/01/03)
In a previous paper we identified several 1-aryl-6,7-dimethoxy-1,2,3,4- tetrahydroisoquinoline-2-sulfonamides that displayed inhibitory effects toward selected carbonic anhydrase isozymes at micromolar concentration. In order to deepen the structure-activ
3D pharmacophore models for 1,2,3,4-tetrahydroisoquinoline derivatives acting as anticonvulsant agents
De Luca, Laura,Gitto, Rosaria,Barreca, Maria Letizia,Caruso, Roberta,Quartarone, Silvana,Citraro, Rita,De Sarro, Giovambattista,Chimirri, Alba
, p. 388 - 400 (2007/10/03)
A 3D pharmacophore model predicting anticonvulsant activity was obtained for a series of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives recently disclosed as a new class of non-competitive AMPA receptor antagonists. The training set included 17
