601463-61-0Relevant academic research and scientific papers
1-Aryl-1,2,3,4-tetrahydroisoquinolines as potential antimalarials: Synthesis, in vitro antiplasmodial activity and in silico pharmacokinetics evaluation
Hanna, Joelle Ngo,Ntie-Kang, Fidele,Kaiser, Marcel,Brun, Reto,Efange, Simon M. N.
, p. 22856 - 22865 (2014/06/24)
In the present study, twenty-one 1-aryl-6-hydroxy-1,2,3,4- tetrahydroisoquinoline (THIQ) analogues were synthesized by base-catalyzed Pictet-Spengler reaction, and tested in vitro against P. falciparum using the [3H]hypoxanthine incorporation a
Calcium-catalyzed pictet-spengler reactions
Vanden Eynden, Matthew J.,Stambuli, James P.
supporting information; experimental part, p. 5289 - 5291 (2009/06/18)
(Chemical Equation Presented) Pictet-Spengler reactions of m-tyramine and aldehydes produced tetrahydroisoquinolines in the presence of a catalytic amount of Ca[OCH(CF3)2]2. This reaction occurs with a variety of aryl, het
