60148-94-9Relevant academic research and scientific papers
Enantioselective synthesis of (R)-(-)2,6-dimethyl heptanoic acid: The first application of the DITOX asymmetric building block
Bulman Page, Philip C.,Allin, Steve M.,Collington, Eric W.,Carr, Robin A. E.
, p. 2607 - 2608 (1994)
The 1,3-dithiane 1-oxide (DITOX) asymmetric building block/chiral auxiliary has been used to prepare (R)-(-)-2,6-dimethyl heptanoic acid (1), a simple derivative of citronellal, in two steps from (2).
Synthesis of chiral alkynes having 2H or halogen at the secondary or tertiary propargylic stereogenic center by hydrolysis and halogenolysis of optically active allenyltitaniums having axial chirality
An, Duk Keun,Okamoto, Sentaro,Sato, Fumie
, p. 4555 - 4558 (1998)
The hydrolysis and halogenolysis of optically active allenyltitaniums, generated by the reaction of a Ti(O-i-Pr)4/2i-PrMgCl reagent with optically active propargyl alcohol derivatives, proceed in a regioselective way and with excellent degree of chiral transfer, thus opening up a highly efficient and practical route to chiral alkynes having 2H or Cl at the stereogenic propargylic center.
Enantioselective synthesis of α-methyl carboxylic acids using a DiTOX chiral auxiliary
Page, Philip C. Bulman,McKenzie, Michael J.,Allin, Steven M.,Klair, Sukhbinder S.
, p. 13149 - 13164 (2007/10/03)
Five α-methyl carboxylic acids have been prepared with high e.e.s using 1,3-dithiane 1-oxide (DiTOX) units as the stereocontrolling elements and sources of chirality.
Synthesis of vitamin E
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, (2008/06/13)
A synthesis of Vitamin E in racemic or optically active forms from 6-methyl-2-hepten-4-ol; 6,10-dimethyl-2-undecen-4-ol or 6-benzyloxy-2,5,7,8-tetramethyl-chroman-2-acetaldehyde including intermediates in this synthesis.
