601487-87-0 Usage
Uses
Used in Pharmaceutical Industry:
Acetamide, N-(5-acetyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluorois utilized as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of drugs with enhanced therapeutic properties. The trifluoromethyl group is known to impart metabolic stability and lipophilicity to the resulting compounds, which can improve their pharmacokinetic and pharmacodynamic profiles.
Used in Agricultural Industry:
In the agricultural sector, Acetamide, N-(5-acetyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoro- is employed as a precursor in the production of agrochemicals, specifically pesticides and herbicides. Its incorporation into these chemicals can lead to improved efficacy against pests and weeds, as well as potentially reducing the environmental impact due to its specific mode of action.
Used as a Reagent in Organic Synthesis:
Acetamide, N-(5-acetyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroalso serves as a valuable reagent in organic synthesis, where it is used to introduce the trifluoromethyl group into various molecular frameworks. This modification can significantly alter the physical, chemical, and biological properties of the target molecules, making it a useful tool for the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.
The diverse applications of Acetamide, N-(5-acetyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluorounderscore its importance in the fields of chemistry and biology, highlighting its potential to contribute to the advancement of new and improved products in medicine and agriculture.
Check Digit Verification of cas no
The CAS Registry Mumber 601487-87-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,0,1,4,8 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 601487-87:
(8*6)+(7*0)+(6*1)+(5*4)+(4*8)+(3*7)+(2*8)+(1*7)=150
150 % 10 = 0
So 601487-87-0 is a valid CAS Registry Number.
601487-87-0Relevant academic research and scientific papers
An efficient and economical synthesis of 5,6-diethyl-2,3-dihydro-1H-inden- 2-amine hydrochloride
Prashad, Mahavir,Hu, Bin,Har, Denis,Repic, Oljan,Blacklock, Thomas J.,Lohse, Olivier
, p. 135 - 141 (2012/12/21)
An efficient and economical synthesis of 5,6-diethyl-2,3-dihydro-1H-inden- 2-amine hydrochloride (1) utilizing 2-aminoindan as a cheap and commercially readily available starting material is described. The newly developed synthesis involves six-steps with 49% overall yield, and it introduces two ethyl groups at the 5- and 6-positions via sequential regioselective Friedel-Crafts acetylations and hydrogenations of N-protected-2-aminoindan. The Friedel-Crafts acetylations can be carried out neat with high regioselectivity using acetyl chloride as the reagent as well as the solvent, thus avoiding the use of halogenated solvents.
Process for preparing 5,6-diethyl-2,3-dihydro-1H-inden-2-amine
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, (2008/06/13)
A process for preparing 5,6-diethyl-2,3-dihydro-1H-inden-2-amine and acid addition salts thereof from 2-aminoindan. The process comprises protecting the amino group of 2-aminoindan, acetylating the ring in the protected compound, reducing the acetyl group to ethyl to form a monoethyl derivative, acetylating the monoethyl derivative, reducing the acetyl group to form a diethyl derivative, deprotecting the latter by hydrolysis and recovering the product in free or salt form. The process does not use deleterious Grignard reagents or nitrites such as isoamyl nitrite, and provides high regioselectivity and high yield of 5,6-diethyl-2,3-dihydro-1H-inden-2-amine. In addition, the process uses acetyl halide as both a reactant and a solvent.
