601495-42-5Relevant articles and documents
New 1-C-(5-thio-D-xylopyranosyl) derivatives as potential orally active venous antithrombotics
Mignon, Laurent,Goichot, Christophe,Ratel, Philippe,Cagnin, Gerald,Baudry, Michel,Praly, Jean-Pierre,Boubia, Benaissa,Barberousse, Veronique
, p. 1271 - 1282 (2007/10/03)
In the search for new orally active antithrombotic drugs that are metabolically stable, we explored the synthesis of 1-C-(5-thio-D-xylosyl) derivatives, examining radical and nucleophilic methods. Thus synthesized were aryl, benzyl, alkylcarboxymethylenyl, arylsulfonylmethylenyl and alkylaminocarboxymethylenyl C-linked analogues of 5-thio-D-xylopyranosides.
