601520-86-9Relevant academic research and scientific papers
Baylis-Hillman reaction assisted parallel synthesis of 3,5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents
Batra,Roy,Patra,Bhaduri,Surin,Raghavan,Sharma,Kapoor,Dikshit
, p. 2059 - 2077 (2007/10/03)
The solution-phase parallel synthesis involving reactions of Baylis-Hillman products of 3-substituted-5-isoxazolecarbaldehydes with nucleophiles and their in vivo antithrombotic evaluations are described along with the results of in vitro platelet aggregation inhibition assay of a few compounds. Results of the detailed evaluation of one of the compounds as an inhibitor of platelet aggregation are also presented.
Isoxazole-based derivatives from Baylis-Hillman chemistry: Assessment of preliminary hypolipidemic activity
Patra,Batra,Bhaduri,Khanna,Chander,Dikshit
, p. 2269 - 2276 (2007/10/03)
The synthesis of isoxazole-based derivatives utilizing Baylis-Hillman chemistry and results of their preliminary bioevaluation as hypolipidemic agents in triton model are described.
