60166-83-8

Basic information

• Product Name: 3-Methoxythiophene-2-carboxylic acid
• Synonyms: 2-Carboxy-3-methoxythiophene;3-Methoxythiophene-2-carboxylic acid
• CAS NO: 60166-83-8
• Molecular Formula: C6H6O3S
• Molecular Weight: 158.17504
• Product Categories: Carboxylic Acids;Thiophenes & Benzothiophenes;Carboxylic Acids;Thiophenes & Benzothiophenes
• Mol File: 60166-83-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 295.7 °C at 760 mmHg
• Flash Point: 132.6 °C
• Appearance: /
• Density: 1.37 g/cm³
• Vapor Pressure: 0.000679mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.66±0.10(Predicted)
• CAS DataBase Reference: 3-Methoxythiophene-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methoxythiophene-2-carboxylic acid(60166-83-8)
• EPA Substance Registry System: 3-Methoxythiophene-2-carboxylic acid(60166-83-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 60166-83-8(Hazardous Substances Data)

Usage

General Description

3-Methoxythiophene-2-carboxylic acid is a chemical compound with the molecular formula C7H6O3S. It is a derivative of thiophene carboxylic acid, containing a methoxy group at the 3-position of the thiophene ring. 3-Methoxythiophene-2-carboxylic acid is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity and ability to form various derivatives. Its unique chemical structure makes it a valuable building block in organic synthesis, and it has shown potential for use in the development of new drug compounds. Additionally, it has been studied for its potential biological and pharmacological activities, making it an important compound in medicinal chemistry research.

InChI:InChI=1/C6H6O3S/c1-9-4-2-3-10-5(4)6(7)8/h2-3H,1H3,(H,7,8)

Upstream product

• 17573-92-1 3-methoxy-thiophene 
• 109-72-8 n-butyllithium 
• 5118-06-9 methyl 3-hydroxy-2-thiophenecarboxylate 
• 74-88-4 methyl iodide 
• 62353-75-7 methyl 3-methoxy-2-thiophenecarboxylate 
• 77-78-1 dimethyl sulfate 
• 497-19-8 sodium carbonate 

Downstream Products

• 17573-92-1 3-methoxy-thiophene 
• 78031-17-1 3-methoxythiophene-2-carboxamide 
• 54450-14-5 3-methoxy-2-thenoyl chloride 

Relevant articles and documents

5-(THIOPHEN-2-YL)-1H-TETRAZOLE DERIVATIVES AS BCKDK INHIBITORS USEFUL FOR TREATING VARIOUS DISEASES

Described herein are compounds of Formula (I), wherein R1, R2, and R3 are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors, pharmaceutical compositions containing such inhibitors

DNA-BINDING POLYMERS

Methods and compositions are provided for forming complexes between dsDNA and novel DNA-binding polymers comprising N-terminal thiophene-containing moieties which exhibit selectivity for T-A base pairs. By appropriate choice of target sequences and DNA-binding polymers, complexes comprising polymer-DNA are obtained with high association constants. The formation of complexes can be used for identification of specific dsDNA sequences, for inhibiting gene transcription, and as a therapeutic for inhibiting proliferation of undesired cells or modulation of expression of specific genes.

3,5-Disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof

Disclosed are 3,5-disubstituted-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, R2, A, B and D are defined herein. The present invention relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.