78031-17-1Relevant academic research and scientific papers
Synthesis and preliminary pharmacological study of thiophene analogues of the antipyretic and analgesic agent ethenzamide
Darias,Bravo,Abdallah,Sanchez Mateo,Exposito-Orta
, p. 83 - 87 (2007/10/02)
A preliminary pharmacologcal study of a thiophene analogue 1b of the analgesic and antipyretic agent Ethenzamide and of a closely related compound 1a showed that a great similarity exists among Ethenzamide and the thiophenic compounds for analgesic, antipyretic, ulcerogenic, hypothermic, and sedative effects. However, the acute toxicity in mice for the thiophenic compounds is notably higher than that of Ethenzamide.
The Fragmentation of 5- and 3-Substituted Thiophene-2-carboxamides Under Electron Impact
Occhipinti, Salvatore,Alberghina, Gaetano,Fisichella, Salvatore,Puglisi, Orazio,Ceraulo, Leopoldo
, p. 632 - 636 (2007/10/02)
The 70 eV electron impact mass spectra of twelve 5- and 3-substituted thiophene-2-carboxamides are discussed with the aid of exact mass measurements and labelling experiments.All mass spectra exhibit pronounced molecular ions.Some isomeric 5- and 3-substituted title compounds can be differentiated by mass spectrometry.The fragmentation is influenced by a strong 'ortho-effect' which activates the NH3 elimination.In the other cases the most important fragmentation is NH2. loss, followed by CO elimination.
