60172-08-9

Basic information

• Product Name: N-(pyridin-4-yl)benzene-1,4-diamine
• CAS NO: 60172-08-9
• Molecular Formula: C₁₁H₁₁N₃
• Molecular Weight: 185.2251
• Mol File: 60172-08-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 382.9°C at 760 mmHg
• Flash Point: 185.4°C
• Density: 1.226g/cm³
• Vapor Pressure: 4.58E-06mmHg at 25°C
• Refractive Index: 1.693
• CAS DataBase Reference: N-(pyridin-4-yl)benzene-1,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(pyridin-4-yl)benzene-1,4-diamine(60172-08-9)
• EPA Substance Registry System: N-(pyridin-4-yl)benzene-1,4-diamine(60172-08-9)

Safety Data

• Hazardous Substances Data: 60172-08-9(Hazardous Substances Data)

Upstream product

• 72109-70-7 4-(2-phenylhydrazin)pyridine 
• 25551-60-4 N-(4-nitrophenyl)-4-pyridinamine 
• 504-24-5 4-aminopyridine 
• 586-78-7 para-nitrophenyl bromide 
• 22752-98-3 N-(4-pyridyl)pyridinium hydrochloride 

Downstream Products

• 23552-71-8 C₁₈H₁₄N₄O₃ 
• 1332220-29-7 4-tert-butyl-N-[[4-(4-pyridylamino)phenyl]-carbamothioyl]benzamide hydrochloride 
• 1020086-91-2 C₁₉H₁₇N₄O₃⁽¹⁺⁾*Cl^(1-) 
• 1020086-93-4 1-methyl-4-{4-[(4-nitroanilino)carbonyl]anilino}pyridinium tosylate 
• 23625-78-7 4-[p-(4-pyridylamino)phenylcarbamoyl]aniline 
• 50440-30-7 4-[(6-nitroquinolin-4-yl)amino]-N-[4-(pyridin-4-ylamino)phenyl]benzamide 

Relevant articles and documents

AKT3 MODULATORS

Compounds of Formula Ia, lb, or Ic, Formula (Ia); Formula (Ib); or Formula (Ic), are described, where the various substituents are defined herein. The compounds can modulate a property or effect of Akt3 in vitro or in vivo, and can also be used, individually or in combination with other agents, in the prevention or treatment of a variety of conditions. Methods for synthesizing the compounds are described. Pharmaceutical compositions and methods of using these compounds or compositions, individually or in combination with other agents or compositions, in the prevention or treatment of a variety of conditions are also described.

SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity

A series of acylthiourea derivatives were designed, synthesized, and evaluated for broad-spectrum antiviral activity with selected viruses from Poxviridae (vaccinia virus) and two different genera of the family Bunyaviridae (Rift Valley fever and La Cross

Acid-catalysed disproportionation and benzidine rearrangement of phenylhydrazinopyridines: Reaction pathways, kinetics and mechanism

A kinetic and product analysis study of the reaction of 4-[N′-(4-hydroxyphenylhydrazino)]pyridine (1) and 4-(N′-phenylhydrazino)pyridine (2) in 10-55 wt% aqueous sulfuric acid media is reported. The final products obtained from 1 are the oxidation product, 4-(4-hydroxyphenylazo)pyridine (3), and the two reduction products 4-aminophenol and 4-aminopyridine. This product pattern resembles that of the disproportionation products observed in some cases of the benzidine rearrangement. The reaction of 2 gives a complex product mixture including the disproportionation products 4-(phenylazo)pyridine (4), aniline and 4-aminopyridine, and other benzidine-type products including a p-semidine. Complicating the situation is the concurrent hydroxylation and disproportionation of 4 which take place in these media, giving 3, 4-aminopyridine and 4-aminophenol. The observed pseudo-first-order rate constants for the disproportionations increase steeply with acid concentration without showing any downturn at higher acidities. The disproportionation rate constants for 1 and 2 are much larger than those for the hydroxylation of 4. A reasonable mechanism which explains the observations is a benzidine-type rearrangement with accompanying disproportionation. To our knowledge this work is the first description of this type of reaction in substrates containing pyridinium rings.