60178-58-7Relevant academic research and scientific papers
Excited-state intramolecular proton transfer in 2-(2′-tosylaminophenyl)benzimidazole
Fahrni, Christoph J.,Henary, Maged M.,VanDerveer, Donald G.
, p. 7655 - 7663 (2002)
The spectroscopic properties of 2-(2′-tosylaminophenyl)benzimidazole (TPBI) have been studied in a series of different solvents. As revealed by absorbance, steady-state, and time-resolved emission spectroscopy, the molecule undergoes fast excited-state in
From sensors to silencers: Quinoline- and benzimidazole-sulfonamides as inhibitors for zinc proteases
Rouffet, Matthieu,De Oliveira, Cesar Augusto F.,Udi, Yael,Agrawal, Arpita,Sagi, Irit,McCammon, J. Andrew,Cohen, Seth M.
supporting information; experimental part, p. 8232 - 8233 (2010/08/05)
Derived from the extensive work in the area of small molecule zinc(II) ion sensors, chelating fragment libraries of quinoline- and benzimidazole- sulfonamides have been prepared and screened against several different zinc(II)-dependent matrix metalloproteinases (MMPs). The fragments show impressive inhibition of these metalloenzymes and preferences for different MMPs based on the nature of the chelating group. The findings show that focused chelator libraries are a powerful strategy for the discovery of lead fragments for metalloprotein inhibition.
