60197-89-9Relevant academic research and scientific papers
Bromine catalyzed conversion of S-tert-butyl groups into versatile and, for self-assembly processes accessible, acetyl-protected thiols
Blaszczyk, Alfred,Elbing, Mark,Mayor, Marcel
, p. 2722 - 2724 (2004)
The facile and efficient conversion of a tert-butyl protecting group to an acetyl protecting group for thiols by catalytic amounts of bromine in acetyl chloride and the presence of acetic acid has been developed. The fairly mild reaction conditions are of
HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES
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Page 6, (2010/02/05)
Compounds having therapeutic utility are of formula (I) B—X—(CH2)n—CR2R3—CR4R5—COY??(I) wherein n =0-1; X is S(O)0-2, Y is OR1 or NHOH; R2 and R4 are independently H or a group (optionally substituted with R10) selected from C1-6 alkyl, C2-6 alkenyl, aryl, C1-6 alkyl-aryl, heteroaryl, C1-6 alkyl-heteroaryl, heterocycloalkyl, C1-6 alkyl-heterocycloalkyl, cycloalkyl and C1-6 alkyl-cycloalkyl; and R1, R3 and R5 are independently H or C1-6 alkyl; provided that not more than two of R2, R3, R4 and R5 are H; or any of CR2R3, CR4R5 and CR2—CR4 is a cycloalkyl or heterocycloalkyl ring optionally substituted with R10 or a group (optionally substituted with R10) selected from C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl and C1-6 alkyl-heteroaryl; B is heterocycloalkyl (optionally substituted by R6 or R7) bonded through carbon to X, or C1-6 alkyl-heterocycloalkyl (optionally substituted with R6 or R7), or a group (substituted with R6) selected from C1-8 alkyl, C2-6 alkenyl and C2-6 alkynyl; R6 is N(R7)2, OR7, COR7, C(=NOR9)R 7, NR7R8, S(O)0-2R9 or SO2N(R7)2; R7 is H or a group selected from C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl, C1-6 alkyl-heteroaryl, cycloalkyl, C1-6 alkyl-cycloalkyl, heterocycloalkyl and C1-6 alkyl-heterocycloalkyl, wherein said group is optionally substituted with R9, COR9, SO0-2R9, CO2R9, OR9, CONR1R9, NR1R9, halogen, CN, SO2NR1R9 or NO2, and for each case of N(R7)2 the R7 groups are the same or different or N(R7)2 is heterocycloalkyl optionally substituted with R9, COR9, SO0-2R9, CO2R9, OR9, CONR1R9, NR1R9, halogen, CN, SO2NR1R9 or NO2; R8 is COR7, CON(R7)2, CO2R9 or SO2R9; R9 is C1-6 alkyl, aryl, C1-6 alkyl-aryl, heteroaryl or C1-6 alkyl-heteroaryl; and R10 is OR7, COR7, CO2R1, CON(R7)2, NR7R8, S(O)0-2R9, SO2N(R7)2, CN, halogen or cycloimidyl (optionally substituted with R1); and the salts, solvates, hydrates, N-oxides, protected amino, protected carboxy and protected hydroxamic acid derivatives thereof.
