60203-57-8 Usage
Uses
Used in Pharmaceutical Industry:
Prostaglandin J2 is utilized as a bioactive compound with potential applications in the development of therapeutic agents. Its anti-neoplastic and antiviral properties make it a promising candidate for the treatment of various diseases, particularly those related to abnormal cell proliferation and viral infections.
Used in Cancer Research:
In the field of cancer research, PGJ2 is employed as a tool to study the mechanisms underlying its antimitotic and antiproliferative effects. This knowledge can contribute to the development of novel cancer therapies that target specific cellular pathways and processes.
Used in Drug Development:
Prostaglandin J2 serves as a lead compound in drug development, where its chemical structure can be modified to enhance its therapeutic potential and reduce potential side effects. This can lead to the creation of new drugs with improved efficacy and safety profiles for the treatment of various diseases.
Used in Platelet Aggregation Studies:
PGJ2 is used as a research tool to investigate the mechanisms of platelet aggregation and its regulation. Understanding these processes can help in the development of treatments for conditions such as thrombosis and other blood clot-related disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 60203-57-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,2,0 and 3 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 60203-57:
(7*6)+(6*0)+(5*2)+(4*0)+(3*3)+(2*5)+(1*7)=78
78 % 10 = 8
So 60203-57-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1
60203-57-8Relevant academic research and scientific papers
First enantioselective total synthesis of (8S,12R,15S)-prostaglandin J2
Zanoni, Giuseppe,Porta, Alessio,de Toma, Quintino,Castronovo, Francesca,Vidari, Giovanni
, p. 6437 - 6439 (2007/10/03)
Enantioselective synthesis of natural PGJ2 has been accomplished for the first time starting from the commercially available enantiopure aldehyde 7 in 10% overall yield. The key reaction was a novel prostaglandin class interconversion, i.e., an
Synthesis of optically active prostaglandin-J2 and 15-deoxy-δ12,14-prostaglandin-J2
Bickley, Jamie F.,Jadhav, Vasudev,Roberts, Stanley M.,Santoro, M. Gabriella,Steiner, Alexander,Sutton, Peter W.
, p. 1170 - 1174 (2007/10/03)
An efficient route to optically pure prostaglandin-J2 compounds has been discovered: ent-PGJ2 is shown to display antiviral activity against Sendai virus with a similar potency to the natural enantiomer.
Preparation and some reactions of 2-oxatricyclo[3.3.0.04,6]oct- 7-en-3-one: Synthesis of 9-deoxa-9,10-dehydroprostaglandin D2
Ali, S. Mubarik,Chapleo, Christopher B.,Finch, Mark A. W.,Roberts, Stanley M.,Woolley, Geoffrey T.,Cave, Richard J.,Newton, Roger F.
, p. 2093 - 2097 (2007/10/02)
The tricyclic lactone (1) was prepared by two methods. Reaction of (1) with electrophilic reagents occurred on the more exposed exo-face of the alkene unit resulting in the formation of the epoxylactone (8) on peracid oxidation and the bromolactones (9)-(11) on bromination in the appropriate solvent. Thiophenoxide ion reacted with (1) in SN2 fashion to give the acid (13) while deuteriation studies suggested that lithium dibutylcuprate reacted with (1) through the SN′ pathway preferentially to give the acid (15). The cuprate reagent (20) reacted with the lactone (1) to form the acid (21) which was converted into the prostanoid (29) in a standard fashion.
