60208-06-2

Basic information

• Product Name: Ethanone, 2-broMo-1-(4-chloro-2-Methoxyphenyl)-
• Synonyms: Ethanone, 2-broMo-1-(4-chloro-2-Methoxyphenyl)-
• CAS NO: 60208-06-2
• Molecular Formula: C₉H₈BrClO₂
• Molecular Weight: 263.51562
• Mol File: 60208-06-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 328.0±27.0 °C(Predicted)
• Appearance: /
• Density: 1.549±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: Ethanone, 2-broMo-1-(4-chloro-2-Methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-broMo-1-(4-chloro-2-Methoxyphenyl)-(60208-06-2)
• EPA Substance Registry System: Ethanone, 2-broMo-1-(4-chloro-2-Methoxyphenyl)-(60208-06-2)

Safety Data

• Hazardous Substances Data: 60208-06-2(Hazardous Substances Data)

Upstream product

• 60207-19-4 1-(4-chloro-2-methoxyphenyl)-ethanone 
• 6921-66-0 4-chloro-2-hydroxy acetophenone 

Relevant articles and documents

Structure-Based Design of N-(5-Phenylthiazol-2-yl)acrylamides as Novel and Potent Glutathione S-Transferase Omega 1 Inhibitors

Using reported glutathione S-transferase omega 1 (GSTO1-1) cocrystal structures, we designed and synthesized acrylamide-containing compounds that covalently bind to Cys32 on the catalytic site. Starting from a thiazole derivative 10 (GSTO1-1 IC50 = 0.6 μM), compound 18 was synthesized and cocrystallized with GSTO1. Modification on the amide moiety of hit compound 10 significantly increased the GSTO1-1 inhibitory potency. We solved the cocrystal structures of new derivatives, 37 and 44, bearing an amide side chain bound to GSTO1. These new structures showed a reorientation of the phenyl thiazole core of inhibitors, 37 and 44, when compared to 18. Guided by the cocrystal structure of GSTO1:44, analogue 49 was designed, resulting in the most potent GSTO1-1 inhibitor (IC50 = 0.22 ± 0.02 nM) known to date. We believe that our data will form the basis for future studies of developing GSTO1-1 as a new drug target for cancer therapy.