60217-07-4

Basic information

• Product Name: 1,3-Propanedione, 1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-
• CAS NO: 60217-07-4
• Molecular Formula: C21H24O9
• Molecular Weight: 420.416
• Mol File: 60217-07-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-Propanedione, 1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Propanedione, 1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-(60217-07-4)
• EPA Substance Registry System: 1,3-Propanedione, 1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-(60217-07-4)

Safety Data

• Hazardous Substances Data: 60217-07-4(Hazardous Substances Data)

Upstream product

• 60217-06-3 3,4,5-trimethoxy-benzoic acid-(2-acetyl-3,4,5-trimethoxy-phenyl ester) 
• 22248-14-2 6-hydroxy-2,3,4-trimethoxyacetophenone 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 

Downstream Products

• 29043-07-0 3',4',5,5',6,7-Hexamethoxyflavone 

Relevant articles and documents

Flavonoids with M1 muscarinic acetylcholine receptor binding activity

Muscarinic acetylcholine receptor- Active compounds have potential for the treatment of Alzheimer's disease. In this study, a series of natural and synthetic flavones and flavonols was assayed in vitro for their ability to inhibit radioligand binding at human cloned M1 muscarinic receptors. Several compounds were found to possess competitive binding affinity (K i = 40-110 μM), comparable to that of acetylcholine (Ki = 59 μM). Despite the fact that these compounds lack a positively-charged ammonium group under physiological conditions, molecular modelling studies suggested that they bind to the orthosteric site of the receptor, mainly through non-polar interactions.