29043-07-0

Basic information

• Product Name: 3',4',5',5,6,7-HEXAMETHOXYFLAVONE
• Synonyms: HEXAMETHOXYFLAVONE, 3',4',5',5,6,7-;3',4',5',5,6,7-HEXAMETHOXYFLAVONE;3',4',5,5',6,7-HEXAMETHOXYFLAVONE;5,6,7,3',4',5'-HEXAMETHOXYFLAVONE;HEXAMETHOXYFLAVONE, 3',4',5',5,6,7-(RG);3'',4'',5,5'',6,7-HEXAMETHOXYFLAVONE 98%;3',4',5,5',6,7-Hexamethoxyflavone
• CAS NO: 29043-07-0
• Molecular Formula: C₂₁H₂₂O₈
• Molecular Weight: 402.39
• Product Categories: Hexa-substituted Flavones
• Mol File: 29043-07-0.mol

Chemical Properties

• Melting Point: 115°C
• Appearance: /
• CAS DataBase Reference: 3',4',5',5,6,7-HEXAMETHOXYFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4',5',5,6,7-HEXAMETHOXYFLAVONE(29043-07-0)
• EPA Substance Registry System: 3',4',5',5,6,7-HEXAMETHOXYFLAVONE(29043-07-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 29043-07-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3',4',5',5,6,7-HEXAMETHOXYFLAVONE is used as an antioxidant agent for its potential to combat inflammation and other diseases, as well as for its anti-microbial and anti-fungal properties, making it a candidate for the development of new therapeutic agents.
Used in Cancer Treatment:
In the field of oncology, 3',4',5',5,6,7-HEXAMETHOXYFLAVONE is used as a potential anti-cancer agent, with its strong antioxidant properties contributing to the fight against various types of cancer.
Used in Cardiovascular Health:
3',4',5',5,6,7-HEXAMETHOXYFLAVONE is used as a protective agent against cardiovascular diseases, supporting overall heart health through its potential to reduce oxidative stress and inflammation associated with these conditions.
Used in Nutraceutical Industry:
As a strong antioxidant with a variety of health benefits, 3',4',5',5,6,7-HEXAMETHOXYFLAVONE is used in the development of dietary supplements and functional foods to promote general health and well-being.
Used in Cosmetic Industry:
Due to its anti-inflammatory and anti-oxidative properties, 3',4',5',5,6,7-HEXAMETHOXYFLAVONE is used in skincare products to protect the skin from environmental damage and promote a healthy complexion.
Further research is necessary to fully understand the mechanisms of action and to explore the potential therapeutic applications of 3',4',5',5,6,7-HEXAMETHOXYFLAVONE across various industries.

Upstream product

• 68708-52-1 3',4',5',5,6,7-hexahydroxyflavone 
• 77-78-1 dimethyl sulfate 
• 60217-07-4 1-(6-hydroxy-2,3,4-trimethoxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-propane-1,3-dione 
• 186581-53-3 diazomethane 
• 93124-90-4 4'-hydroxy-3',5,5',6,7-pentamethoxyflavone 
• 76015-42-4 5,7,4′-trihydroxy-6,3′,5′-trimethoxyflavone 
• 29215-55-2 5-hydroxyl-6,7,3′,4′,5′-pentamethoxyflavone 
• 111537-41-8 5,3‘-dihydroxy-6,7,4‘,5‘-tetramethoxyflavone 
• 22248-14-2 6-hydroxy-2,3,4-trimethoxyacetophenone 
• 14588-60-4 4-(benzyloxy)-3,5-dimethoxybenzoic acid 
• 89354-95-0 4'-benzyloxy-5,6,7,3',5'-pentamethoxyflavone 
• 89354-97-2 2-hydroxy-4'-benzyloxy-3',4,5,5',6-pentamethoxydibenzoylmethane 
• 89354-96-1 2-(3',5'-dimethoxy-4'-benzyloxy)benzoyloxy-4,5,6-trimethoxyacetophenone 
• 60217-06-3 3,4,5-trimethoxy-benzoic acid-(2-acetyl-3,4,5-trimethoxy-phenyl ester) 

Downstream Products

• 118-41-2 Eudesmic acid 
• 29215-55-2 5-hydroxyl-6,7,3′,4′,5′-pentamethoxyflavone 

Relevant articles and documents

Highly oxygenated flavonoids from Murraya paniculata

Eight highly oxygenated flavones, including one new compound, were isolated from the leaves of an Indonesian medicinal plant, Murraya paniculata. Seven of them were identified as 5-hydroxy-6,7,8,3',4',5'- hexamethoxyflavone (gardenin A), 5,3'-dihydroxy-6,7,8,4',5'- pentamethoxyflavone (gardenin C), 6,7,8,4'-tetra-methoxy-5,3',5'- trihydroxyflavone (gardenin E), 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone (5- O-desmethylnobiletin), 6,7,8,3',4',5'-hexamethoxyflavone, 5-hydroxy- 6,7,3',4',5'-pentamethoxyflavone (umhengerin), 5,3'-dihydroxy-6,7,4',5'- tetramethoxyflavone either by direct comparison with authentic samples or by comparing their melting points and spectroscopic data with those reported in the literature. The new compound was elucidated as 5,3',5'-trihydroxy- 6,7,4'-trimethoxyflavone on the basis of chemical and spectroscopic studies.

ISOLATION AND SYNTHESIS OF TWO NEW FLAVONES FROM CONOCLINIUM COELESTINUM

Two new flavones, 3',4'-methylenedioxy-5,6,7,8,5'-pentamethoxyflavone and 5,7,4'-trihydroxy-6,3',5'-trimethoxyflavone, have been isolated from Conoclinium coelestinum.Final structure proof was accomplished by synthesis.Key Word Index - Conoclinium coelestinum; Compositae; Eupatorieae; flavones; 3',4'-methylenedioxy-5,6,7,8,5'-pentamethoxyflavone; 5,7,4'-trihydroxy-6,3',5'-trimethoxyflavone.

Synthesis and anti-proliferative activities of 5,6,7-trimethoxyflavones and their derivatives

A series of 5,6,7-trimethoxyflavones 1a-1g and their derivatives 2a-2g, 3a-3d, 4 and 5, including the natural products 5,6,7-trimethoxy-4’-hydroxyflavone (1a), 5,6,7,3’,4’ -pentamethoxyflavone (sinensetin, 1 b), 5,6,7-trimethoxy-3’,4’-methyl enedioxy flavone (1c), 5,6,7,3’-tetramethoxy-4,5’-methylenedioxyflavone (1e), 5,6,7, 3’,4’,5’-hextamethoxyflavone (1 g), 5-hydroxy-3,4,2’,3’,4’-pentamethoxy chal-cone (2 b), 5,4’-dihydroxy-6,7-dimethoxy flavone (cirsimaritin, 3a) and 5-hydroxy-6,7,3’, 4’-tetramethoxyflavone (5-demethylsinensetin, 3 b), 3,5,6,7,3’,4’-hexamethoxyflavone (3-methoxysinensetin, 4) and 5’-hydroxy-3,6,7,3’,4’-pentamethoxyflavone (5) were synthesized. Their anti-proliferative activity in?vitro was evaluated against a panel of four human cancer cell lines (Aspc-1, HCT-116, HepG-2 and SUN-5) by the CTG assay. The results showed that most of the synthetic compounds exhibited moderate to high anti-proliferative activities. In particular, compound 3c possess IC50 (5.30 μM) values below 10 μM against Aspc-1 cells and are worthy of further investigation.

Use of flavone and flavanone derivatives in preparation of sedative and hypnotic drugs

Disclosed is a use of flavones derivatives and flavanone derivatives in preparation of sedative and hypnotic drugs.

USE OF FLAVONE AND FLAVANONE DERIVATIVES IN PREPARATION OF SEDATIVE AND HYPNOTIC DRUGS

Disclosed is a use of flavones derivatives and flavanone derivatives in preparation of sedative and hypnotic drugs.

Flavonoids with M1 muscarinic acetylcholine receptor binding activity

Muscarinic acetylcholine receptor- Active compounds have potential for the treatment of Alzheimer's disease. In this study, a series of natural and synthetic flavones and flavonols was assayed in vitro for their ability to inhibit radioligand binding at human cloned M1 muscarinic receptors. Several compounds were found to possess competitive binding affinity (K i = 40-110 μM), comparable to that of acetylcholine (Ki = 59 μM). Despite the fact that these compounds lack a positively-charged ammonium group under physiological conditions, molecular modelling studies suggested that they bind to the orthosteric site of the receptor, mainly through non-polar interactions.

POLYOXYGENATED FLAVONES FROM AGERATUM CONYZOIDES

Key Word Index - Ageratum conyzoides; Asteraceae; 5,6,7-trimethoxy-3',4'-methylenedioxyflavone; 5,6,7,3'-tetramethoxy-4'-hydroxyflavone; 5,6,7,3',5'-pentamethoxy-4'-hydroxyflavone; polyoxygenated flavones.Twelve polyoxygenated flavones have been isolated from Ageratum conyzoides, three of which are new natural flavones, namely ageconyflavones A (5,6,7-trimethoxy-3',4'-methylenedioxyflavone), B (5,6,7,3'-tetramethoxy-4'-hydroxyflavone) and C (5,6,7,3',5'-pentamethoxy-4'-hydroxyflavone).The other nine compounds were identified as linderoflavone B, eupalestin, nobiletin, 5'-methoxynobiletin, 5,6,7,5'-tetramethoxy-3',4'-methylenedioxyflavone, sinensetin, 5,6,7,3',4',5'-hexamethoxyflavone, 5,6,7,8,3'-pentamethoxy-4'-hydroxyflavone and 5,6,7,8,3',5'-hexamethoxy-4'-hydroxyflavone.

Synthetic Studies on the Flavone Derivatives. XII. Synthesis of 2',3',5'- and 3',4',5'-Trioxygenated Flavones

Two unusual flavones, 5,5'-dihydroxy-2',3',6,7-tetramethoxyflavone (1) from Gardenia cramerii and 4',5-dihydroxy-3',5',6,7-tetramethoxyflavone (6) from Artemisia mesatlantia, and their position isomers were synthesized to investigate the structural correlation in terms of spectral data.The structure of the flavone from G. cramerii is discussed.Keywords: 5,5'-dihydroxy-2',3',6,7-tetramethoxyflavone; 2',5-dihydroxy-3',5',6,7-tetramethoxyflavone; 5-hydroxy-2',3',5',6,7-pentamethoxyflavone; 3',5-dihydroxy-4',5',6,7-tetramethoxyflavone; 4',5-dihydroxy-3',5',6,7-tetramethoxyflavone; 5-hydroxy-3',4',5',6,7-pentamethoxyflavone.