29043-07-0Relevant articles and documents
Highly oxygenated flavonoids from Murraya paniculata
Kinoshita, Takeshi,Firman, Kurnia
, p. 1207 - 1210 (1996)
Eight highly oxygenated flavones, including one new compound, were isolated from the leaves of an Indonesian medicinal plant, Murraya paniculata. Seven of them were identified as 5-hydroxy-6,7,8,3',4',5'- hexamethoxyflavone (gardenin A), 5,3'-dihydroxy-6,7,8,4',5'- pentamethoxyflavone (gardenin C), 6,7,8,4'-tetra-methoxy-5,3',5'- trihydroxyflavone (gardenin E), 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone (5- O-desmethylnobiletin), 6,7,8,3',4',5'-hexamethoxyflavone, 5-hydroxy- 6,7,3',4',5'-pentamethoxyflavone (umhengerin), 5,3'-dihydroxy-6,7,4',5'- tetramethoxyflavone either by direct comparison with authentic samples or by comparing their melting points and spectroscopic data with those reported in the literature. The new compound was elucidated as 5,3',5'-trihydroxy- 6,7,4'-trimethoxyflavone on the basis of chemical and spectroscopic studies.
Synthesis and anti-proliferative activities of 5,6,7-trimethoxyflavones and their derivatives
Li, Wei,Liu, Kexiong,Su, Liang,Wang, Qiuan
, (2021/08/12)
A series of 5,6,7-trimethoxyflavones 1a-1g and their derivatives 2a-2g, 3a-3d, 4 and 5, including the natural products 5,6,7-trimethoxy-4’-hydroxyflavone (1a), 5,6,7,3’,4’ -pentamethoxyflavone (sinensetin, 1 b), 5,6,7-trimethoxy-3’,4’-methyl enedioxy flavone (1c), 5,6,7,3’-tetramethoxy-4,5’-methylenedioxyflavone (1e), 5,6,7, 3’,4’,5’-hextamethoxyflavone (1 g), 5-hydroxy-3,4,2’,3’,4’-pentamethoxy chal-cone (2 b), 5,4’-dihydroxy-6,7-dimethoxy flavone (cirsimaritin, 3a) and 5-hydroxy-6,7,3’, 4’-tetramethoxyflavone (5-demethylsinensetin, 3 b), 3,5,6,7,3’,4’-hexamethoxyflavone (3-methoxysinensetin, 4) and 5’-hydroxy-3,6,7,3’,4’-pentamethoxyflavone (5) were synthesized. Their anti-proliferative activity in?vitro was evaluated against a panel of four human cancer cell lines (Aspc-1, HCT-116, HepG-2 and SUN-5) by the CTG assay. The results showed that most of the synthetic compounds exhibited moderate to high anti-proliferative activities. In particular, compound 3c possess IC50 (5.30 μM) values below 10 μM against Aspc-1 cells and are worthy of further investigation.
USE OF FLAVONE AND FLAVANONE DERIVATIVES IN PREPARATION OF SEDATIVE AND HYPNOTIC DRUGS
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Paragraph 0223; 0238, (2015/07/22)
Disclosed is a use of flavones derivatives and flavanone derivatives in preparation of sedative and hypnotic drugs.