6023-96-7 Usage
General Description
2-(5-Nitrofuran-2-yl)quinazolin-4(3H)-one is a chemical compound with the molecular formula C11H7N3O3. It is a derivative of quinazolin-4(3H)-one, which is a heterocyclic compound that contains a quinazoline ring system. The presence of a nitrofuran group in the molecule makes it potentially useful for various biological and pharmaceutical applications due to its ability to interact with biological systems. It may have antibacterial, antifungal, or antiparasitic properties, and could also be used in the development of new drug compounds. As with any chemical compound, its specific properties and potential uses would need to be further investigated through research and testing.
Check Digit Verification of cas no
The CAS Registry Mumber 6023-96-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,2 and 3 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6023-96:
(6*6)+(5*0)+(4*2)+(3*3)+(2*9)+(1*6)=77
77 % 10 = 7
So 6023-96-7 is a valid CAS Registry Number.
6023-96-7Relevant articles and documents
Synthesis and structure–activity relationship study of novel quinazolinone-based inhibitors of MurA
Hrast, Martina,Ro?man, Kaja,Juki?, Marko,Patin, Delphine,Gobec, Stanislav,Sova, Matej
supporting information, p. 3529 - 3533 (2017/07/07)
MurA is an intracellular bacterial enzyme that is essential for peptidoglycan biosynthesis, and is therefore an important target for antibacterial drug discovery. We report the synthesis, in silico studies and extensive structure–activity relationships of a series of quinazolinone-based inhibitors of MurA from Escherichia coli. 3-Benzyloxyphenylquinazolinones showed promising inhibitory potencies against MurA, in the low micromolar range, with an IC50 of 8?μM for the most potent derivative (58). Furthermore, furan-substituted quinazolinones (38, 46) showed promising antibacterial activities, with MICs from 1?μg/mL to 8?μg/mL, concomitant with their MurA inhibitory potencies. These data represent an important step towards the development of novel antimicrobial agents to combat increasing bacterial resistance.
