6023-96-7 Usage
Uses
Used in Pharmaceutical Industry:
2-(5-Nitrofuran-2-yl)quinazolin-4(3H)-one is used as a potential active pharmaceutical ingredient for its potential antibacterial, antifungal, or antiparasitic properties. Its unique molecular structure allows it to interact with biological systems, making it a candidate for the development of new drug compounds.
Used in Research and Development:
2-(5-Nitrofuran-2-yl)quinazolin-4(3H)-one is used as a research compound for further investigation into its specific properties and potential uses. This includes exploring its interactions with biological systems and assessing its efficacy in various applications, such as antimicrobial or antiparasitic treatments. Further research and testing are necessary to fully understand its capabilities and potential applications.
Check Digit Verification of cas no
The CAS Registry Mumber 6023-96-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,2 and 3 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6023-96:
(6*6)+(5*0)+(4*2)+(3*3)+(2*9)+(1*6)=77
77 % 10 = 7
So 6023-96-7 is a valid CAS Registry Number.
6023-96-7Relevant academic research and scientific papers
Synthesis and structure–activity relationship study of novel quinazolinone-based inhibitors of MurA
Hrast, Martina,Ro?man, Kaja,Juki?, Marko,Patin, Delphine,Gobec, Stanislav,Sova, Matej
supporting information, p. 3529 - 3533 (2017/07/07)
MurA is an intracellular bacterial enzyme that is essential for peptidoglycan biosynthesis, and is therefore an important target for antibacterial drug discovery. We report the synthesis, in silico studies and extensive structure–activity relationships of a series of quinazolinone-based inhibitors of MurA from Escherichia coli. 3-Benzyloxyphenylquinazolinones showed promising inhibitory potencies against MurA, in the low micromolar range, with an IC50 of 8?μM for the most potent derivative (58). Furthermore, furan-substituted quinazolinones (38, 46) showed promising antibacterial activities, with MICs from 1?μg/mL to 8?μg/mL, concomitant with their MurA inhibitory potencies. These data represent an important step towards the development of novel antimicrobial agents to combat increasing bacterial resistance.
