60230-37-7

Basic information

• Product Name: 2,6-Difluorobenzenesulfonamide
• Synonyms: BUTTPARK 27\04-28;2,6-DIFLUOROBENZENESULFONAMIDE;2,6-DIFLUOROBENZENESULPHONAMIDE;Benzenesulfonamide, 2,6-difluoro- (9CI);Benzenesulfonamide 2,6-difluoro-;2,6-difluorobenzene-1-sulfonaMide
• CAS NO: 60230-37-7
• Molecular Formula: C₆H₅F₂NO₂S
• Molecular Weight: 193.17
• Product Categories: SULFONAMIDE;Fluorobenzene;Benzenes;Organic Building Blocks;Sulfonamides/Sulfinamides;Sulfur Compounds;Aryl Fluorinated Building Blocks;Building Blocks;C6;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Sulfur Compounds
• Mol File: 60230-37-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 187-191 °C(lit.)
• Boiling Point: 309.2°C at 760 mmHg
• Flash Point: 140.8°C
• Appearance: /
• Density: 1.523g/cm³
• Vapor Pressure: 0.00065mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.31±0.60(Predicted)
• CAS DataBase Reference: 2,6-Difluorobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Difluorobenzenesulfonamide(60230-37-7)
• EPA Substance Registry System: 2,6-Difluorobenzenesulfonamide(60230-37-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-37-26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 60230-37-7(Hazardous Substances Data)

Usage

Uses

2,6-Difluorobenzenesulfonamide can be prepared from N-(4-chlorophenyl)-N′-[(2,6-di fluorophenyl)-sulfonyl]urea.

General Description

2,6-Difluorobenzenesulfonamide is a fluorinated benzenesulfonamide that can be prepared by reacting 2,6-difluorobenzenesulfonyl chloride with 29% ammonium hydroxide. It forms complexes with human carbonic anhydrase II (HCA). X-ray crystal structure of these complexes have been studied.

InChI:InChI=1/C6H5F2NO2S/c7-4-2-1-3-5(8)6(4)12(9,10)11/h1-3H,(H2,9,10,11)

Upstream product

• 60230-36-6 2,6-difluorobenzene-1-sulfonyl chloride 
• 5509-65-9 2,6-difluoroaniline 

Downstream Products

• 1562409-05-5 C₂₃H₂₅F₂N₃O₇S 
• 1562409-09-9 C₂₈H₂₉F₂N₃O₇S₂ 
• 1610042-48-2 N-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2,6-difluorobenzenesulfonamide 
• 1204573-41-0 2-cyclopropylamino-6-fluorobenzenesulphonamide 
• 1204573-42-1 4-cyclopropyl-8-fluoro-4H-1,2,4-benzothiadiazine 1,1-dioxide 
• 1204573-40-9 4-cyclopropyl-8-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide 
• 923243-84-9 2,6-difluoro-N-methyl-benzenesulfonamide 

Relevant articles and documents

2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(amino-oxo-aryl-λ6- sulfanylidene)acetamide compounds (referred to herein as ANASIA compounds) that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-tRNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.

Insect growth regulators. Analogues of TH-6038 and TH-6040.

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