602307-06-2Relevant academic research and scientific papers
Highly practical and enantioselective Cu-catalyzed conjugate addition of alkylzinc reagents to cyclic enones at ambient temperature
Krauss, Isaac J.,Leighton, James L.
, p. 3201 - 3203 (2003)
(Matrix presented) A new ligand for Cu-catalyzed enantioselective additions of dialkylzincs to cyclic enones has been developed. In addition to providing good to excellent enantioselectivities with a range of cyclic enones and dialkylzincs, the ligand has several notworthy features: it can be readily prepared in just two steps, is an air-stable crystalline solid, and provides optimal performance at ambient temperature.
Enantioselective copper-catalyzed 1,4-addition of dialkylzincs to enones followed by trapping with allyl iodide derivatives
Kawamura, Kenjiro,Fukuzawa, Hitomi,Hayashi, Masahiko
, p. 640 - 647 (2011/08/06)
Enantioselective copper-catalyzed 1,4-addition of dialkylzincs to enones proceeded in the presence of 0.1 mol% of Cu(OTf)2 and 0.25 mol% of an N,N,P-ligand containing a quinoline moiety to afford the corresponding conjugated adducts in 99%ee. The intermediate zinc enolates were trapped with substituted allyl iodides to give disubstituted ketones with high diastereoselectivity and enantioselectivity.
Novel N,N,P-tridentate ligands for the highly enantioselective copper-catalyzed 1,4-addition of dialkylzincs to enones
Kawamura, Kenjiro,Fukuzawa, Hitomi,Hayashi, Masahiko
supporting information; experimental part, p. 3509 - 3512 (2009/05/07)
(Chemical Equation Presented) Use of 0.25 mol % of the N,N,P-tridentate ligand containing the 2-quinolyl moiety (1 and 2) and 0.1 mol % of Cu(OTf) 2 enabled the enantioselective 1,4-addition of dialkylzincs to cyclic enones to produce 1,4-adduc
