60234-91-5Relevant academic research and scientific papers
A general synthesis of (2Z)-terpenoic acids
Cahard, Dominique,Mammeri, Malika,Poirier, Jean-Marie,Duhamel, Lucette
, p. 3619 - 3622 (2007/10/03)
A three-step synthesis of (2Z), (4E)-polyenic acids 6 is described. Condensation of aldehydes 1 with potassium prenal enolate led to dihydropyranols 3 which were oxidized into dihydropyrones 5, precursors of (2Z), (4E)-polyenic acids 6. The procedure was applied to a synthesis of 13- cis-retinoic acids from β-ionylidene acetaldehydes. (C) 2000 Elsevier Science Ltd.
A tentative descriptive modelling of chemical structure-biological activity relationships. Biological evaluation of a series of polyethylenic acids
Valla,Giraud,Dore
, p. 295 - 301 (2007/10/02)
48 new polyethylenic-malonic acids have been submitted to an antimicrobial and antifungal screening. After a suitable recoding, the experimental results were analyzed according to two mathematical multivariate analysis using a computer process i.e. Correspondence Factorial Analysis and Cluster Analysis. These methods allowed an accurate study of the structure of the system and a thorough investigation of the structure-activity-specificity relationships. On the other side, magnitude and/or specificity of the observed biological effects were related to structural features. These results should be useful in order to elaborate synthetic strategies.
