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60254-95-7

60254-95-7

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60254-95-7 Usage

Description

5-Hydroxymebendazole is the one metabolite of Benzimidazoles. Benzimidazoles are safe, broad-spectrum anthelmintic drugs and are widely used for prevention and treatment of parasitic infections in food-producing animals.

Chemical Properties

White to Off-White Solid

Uses

The reduced metabolite of Mebendazole (M200500).

Check Digit Verification of cas no

The CAS Registry Mumber 60254-95-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,2,5 and 4 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 60254-95:
(7*6)+(6*0)+(5*2)+(4*5)+(3*4)+(2*9)+(1*5)=107
107 % 10 = 7
So 60254-95-7 is a valid CAS Registry Number.
InChI:InChI=1/C16H15N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9,14,20H,1H3,(H2,17,18,19,21)

60254-95-7 Well-known Company Product Price

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  • Sigma-Aldrich

  • (35404)  5-Hydroxymebendazole  VETRANAL™, analytical standard

  • 60254-95-7

  • 35404-10MG

  • 2,389.14CNY

  • Detail

60254-95-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl {6-[hydroxy(phenyl)methyl]-1H-benzimidazol-2-yl}carbamate

1.2 Other means of identification

Product number -
Other names 5-Hydroxylaminopyridin-2-carbonsaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:60254-95-7 SDS

60254-95-7Downstream Products

60254-95-7Relevant articles and documents

Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1

Zhang, Zhongsheng,Ojo, Kayode K.,Johnson, Steven M.,Larson, Eric T.,He, Penqing,Geiger, Jennifer A.,Castellanos-Gonzalez, Alejandro,White Jr., A. Clinton,Parsons, Marilyn,Merritt, Ethan A.,Maly, Dustin J.,Verlinde, Christophe L.M.J.,Van Voorhis, Wesley C.,Fan, Erkang

scheme or table, p. 5264 - 5267 (2012/09/07)

Calcium-dependent protein kinase-1 (CDPK1) from Cryptosporidium parvum (CpCDPK1) and Toxoplasma gondii (TgCDPK1) have become attractive targets for discovering selective inhibitors to combat infections caused by these protozoa. We used structure-based design to improve a series of benzoylbenzimidazole-based compounds in terms of solubility, selectivity, and potency against CpCDPK1 and TgCDPK1. The best inhibitors show inhibitory potencies below 50 nM and selectivity well above 200-fold over two human kinases with small gatekeeper residues.

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