60261-53-2 Usage
Uses
Used in Pharmaceutical Industry:
2-(4-Benzyl-piperazin-1-yl-methyl)aniline is used as an intermediate or building block for the synthesis of various drugs and pharmaceutical compounds, contributing to the development of new therapeutic agents.
Used in Drug Development:
2-(4-Benzyl-piperazin-1-yl-methyl)aniline is used in the research and development of new therapeutic agents, leveraging its potential pharmacological activity and interactions with biological targets to create innovative treatments for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 60261-53-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,2,6 and 1 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 60261-53:
(7*6)+(6*0)+(5*2)+(4*6)+(3*1)+(2*5)+(1*3)=92
92 % 10 = 2
So 60261-53-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H23N3/c19-18-9-5-4-8-17(18)15-21-12-10-20(11-13-21)14-16-6-2-1-3-7-16/h1-9H,10-15,19H2
60261-53-2Relevant academic research and scientific papers
Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists
De Lucca, George V.,Kim, Ui T.,Johnson, Curt,Vargo, Brian J.,Welch, Patricia K.,Covington, Maryanne,Davies, Paul,Solomon, Kimberly A.,Newton, Robert C.,Trainor, George L.,Decicco, Carl P.,Ko, Soo S.
, p. 3794 - 3804 (2007/10/03)
Structure-activity relationship (SAR) studies of initial screening hits from our corporate library of compounds and a structurally related series of CCR1 receptor antagonists were used to determine that an N-(alkyl)benzylpiperidine is an essential pharmacophore for selective CCR3 antagonists. Further SAR studies that introduced N-(ureidoalkyl) substituents improved the binding potency of these compounds from the micromolar to the low nanomolar range. This new series of compounds also displays highly potent, in vitro functional CCR3-mediated antagonism of eotaxin-induced Ca2+ mobilization and chemotaxis of human eosinophils.
