60261-53-2 Usage
General Description
The chemical 2-(4-Benzyl-piperazin-1-yl-methyl)aniline is a compound with a molecular formula C19H24N2. It is also known by the name "N-(4-benzylpiperazin-1-ylmethyl)aniline" and is a member of the piperazine class of compounds. This chemical is used in the pharmaceutical industry as an intermediate or building block in the synthesis of various drugs and pharmaceutical compounds. It has also been studied for its potential use in the development of new therapeutic agents. The compound is known for its ability to interact with certain biological targets and its potential pharmacological activity, making it of interest to researchers and developers in the pharmaceutical field.
Check Digit Verification of cas no
The CAS Registry Mumber 60261-53-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,2,6 and 1 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 60261-53:
(7*6)+(6*0)+(5*2)+(4*6)+(3*1)+(2*5)+(1*3)=92
92 % 10 = 2
So 60261-53-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H23N3/c19-18-9-5-4-8-17(18)15-21-12-10-20(11-13-21)14-16-6-2-1-3-7-16/h1-9H,10-15,19H2
60261-53-2Relevant articles and documents
Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists
De Lucca, George V.,Kim, Ui T.,Johnson, Curt,Vargo, Brian J.,Welch, Patricia K.,Covington, Maryanne,Davies, Paul,Solomon, Kimberly A.,Newton, Robert C.,Trainor, George L.,Decicco, Carl P.,Ko, Soo S.
, p. 3794 - 3804 (2007/10/03)
Structure-activity relationship (SAR) studies of initial screening hits from our corporate library of compounds and a structurally related series of CCR1 receptor antagonists were used to determine that an N-(alkyl)benzylpiperidine is an essential pharmacophore for selective CCR3 antagonists. Further SAR studies that introduced N-(ureidoalkyl) substituents improved the binding potency of these compounds from the micromolar to the low nanomolar range. This new series of compounds also displays highly potent, in vitro functional CCR3-mediated antagonism of eotaxin-induced Ca2+ mobilization and chemotaxis of human eosinophils.
