6027-95-8

Usage

Uses

Used in Pharmaceutical Research and Development:
Alpha-((MethylaMino)Methyl)benzeneMethanol hydrochloride is used as a precursor or intermediate for the synthesis of various drugs, contributing to the development of new medicinal compounds.
Used in Organic Synthesis:
As a reagent, alpha-((MethylaMino)Methyl)benzeneMethanol hydrochloride aids in the formation of complex organic molecules, facilitating chemical reactions in research and industrial applications.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
alpha-((MethylaMino)Methyl)benzeneMethanol hydrochloride is employed as a chiral auxiliary to assist in asymmetric synthesis, helping to control the stereochemistry of reactions and produce enantiomerically pure products, which is crucial in the production of pharmaceuticals where stereochemistry can affect biological activity.
Used in Drug Discovery:
Alpha-((MethylaMino)Methyl)benzeneMethanol hydrochloride serves as a building block in drug discovery, enabling the creation of diverse pharmaceutical compounds with potential therapeutic applications.

InChI:InChI=1/C9H13NO/c1-10-7-9(11)8-5-3-2-4-6-8/h2-6,9-11H,7H2,1H3/t9-/m1/s1

Upstream product

• 68579-60-2 2-(methylamino)-1-phenylethanol 
• 100-42-5 styrene 
• 88953-56-4 3-methyl-5-phenyloxazolidine 

Relevant academic research and scientific papers

Method for synthesizing N-methylphenethyl ethanolamine and hydrochloride thereof

The invention relates to a method for synthesizing N-methylphenethyl ethanolamine and hydrochloride thereof, and belongs to the technical field of organic synthesis. The method comprises the following steps: dissolving styrene and sodium chloride in a mixed solvent, sequentially adding sulfuric acid aqueous solution and sodium periodate at negative 5-5 DEG C, heating and stirring to react, adding a sodium thiosulfate aqueous solution for a quenching reaction, regulating the pH value to be 8, extracting and concentrating to obtain intermediate (I); adding a methylamine aqueous solution into a reaction bottle, slowly dropwise adding the intermediate (I) into the reaction bottle, stirring overnight at room temperature, performing HPLC detection reaction, and concentrating at reduced pressure to obtain the N-methylphenethyl ethanolamine. In the method for synthesizing N-methylphenethyl ethanolamine, raw materials have low price and are easily available, a low-price conventional reagent is adopted as the reagent, so that the method has low synthesizing cost, mild reaction condition and high conversion rate; and the prepared N-methylphenethyl ethanolamine and hydrochloride thereof have high yield and high purity, and have high quality.

Reagents for Storage and Regeneration of Nonstabilized Azomethine Ylides: Spiroanthraceneoxazolidines

Nonstabilized azomethine ylides are easily trapped by anthraquinone to form stable spiro-oxazolidines, which have an unusual ability to undergo a cycloreversion in the presence of other dipolarophiles at 120-150°C. All tested recycloadditions with carbonyl compounds and electron-poor alkenes occurred in moderate to high yields (41-92%). Moreover, increasing the reaction temperature to 210°C made it possible to obtain adducts with low reactive dipolarophiles.