60278-07-1Relevant articles and documents
2-Benzyl-2-hydroxycyclohexanone
Mccullough, Kevin J.,Perner, Iris,Rosair, Georgina M.
, p. 268 - 270 (1999)
In the solid state, the title compound (C13H16O2) exists as dimers related by a centre of inversion and linked by two equivalent hydrogen bonds O1...H2(-x, 2 - y, 1 - z) [2.021 (3) A]. The carbonyl- and hydroxyl-group O at
Bronsted Acid Mediated Direct α-Hydroxylation of Cyclic α-Branched Ketones
Shevchenko, Grigory A.,Dehn, Stefanie,List, Benjamin
supporting information, p. 2298 - 2300 (2018/10/20)
We report a Bronsted acid mediated direct α-hydroxylation of cyclic α-branched ketones via a tandem aminoxylation/N-O bond-cleavage process. Nitrosobenzene is used as the oxidant and subsequently promotes the liberation of the free alcohol. The desired pr
Highly efficient C-H hydroxylation of carbonyl compounds with oxygen under mild conditions
Liang, Yu-Feng,Jiao, Ning
supporting information, p. 548 - 552 (2014/01/23)
A transition-metal-free Cs2CO3-catalyzed α-hydroxylation of carbonyl compounds with O2 as the oxygen source is described. This reaction provides an efficient approach to tertiary α-hydroxycarbonyl compounds, which are highly valued chemicals and widely used in the chemical and pharmaceutical industry. The simple conditions and the use of molecular oxygen as both the oxidant and the oxygen source make this protocol very environmentally friendly and practical. This transformation is highly efficient and highly selective for tertiary C(sp3)-H bond cleavage. OH, so simple! A transition-metal-free Cs2CO 3-catalyzed α-hydroxylation of carbonyl compounds with O 2 provided a variety of tertiary α-hydroxycarbonyl compounds (see scheme; DMSO=dimethyl sulfoxide), which are widely used in the chemical and pharmaceutical industry. The simple conditions and the use of molecular oxygen as both the oxidant and the oxygen source make this protocol very efficient and practical.
Organic-inorganic hybrid polymer-encapsulated magnetic nanobead catalysts
Arai, Takayoshi,Sato, Toru,Kanoh, Hirofumi,Kaneko, Katsumi,Oguma, Koichi,Yanagisawa, Akira
, p. 882 - 885 (2008/09/21)
A new strategy for the encapsulation of magnetic nanobeads was developed by using the in situ self-assembly of an organic-inorganic hybrid polymer. The hybrid polymer of {[Cu-(bpy)(BF4)2(H2O) 2](bpy)}n (bpy = 4,4′-bipyridine) was constructed on the surface of amino-functionalized magnetic beads and the resulting hybrid-polymer-encapsulated beads were utilized as catalysts for the oxidation of silyl enolates to provide the corresponding α-hydroxy carbonyl compounds in high yield. After the completion of the reaction, the catalyst was readily recovered by magnetic separation and the recovered catalyst could be reused several times. Because the current method did not require complicated procedures for incorporating the catalyst onto the magnetic beads, the preparation and the application of various other types of organic-inorganic hybrid-polymer-coated magnetic beads could be possible.
