60283-14-9 Usage
General Description
1-(2-amino-5-piperidinophenyl)-1-ethanone is a chemical compound with the molecular formula C14H19N3O. It is an organic compound that contains a piperidine ring, an amino group, and a ketone group. The compound is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It has potential applications in the development of drugs for various conditions, including neurological disorders and cancer. The compound's structure and properties make it a valuable building block for the creation of new and innovative molecules with therapeutic potential. Overall, 1-(2-amino-5-piperidinophenyl)-1-ethanone is an important chemical in the field of organic chemistry and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 60283-14-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,2,8 and 3 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 60283-14:
(7*6)+(6*0)+(5*2)+(4*8)+(3*3)+(2*1)+(1*4)=99
99 % 10 = 9
So 60283-14-9 is a valid CAS Registry Number.
InChI:InChI=1/C13H18N2O/c1-10(16)12-9-11(5-6-13(12)14)15-7-3-2-4-8-15/h5-6,9H,2-4,7-8,14H2,1H3
60283-14-9Relevant articles and documents
Synthesis and Cardiotonic Activity of a Series of Substituted 4-Alkyl-2(1H)-quinazolinones
Bandurco, Victor T.,Schwender, Charles F.,Bell, Stanley C.,Combs, Donald W.,Kanojia, Ramesh M.,et al.
, p. 1421 - 1426 (2007/10/02)
The synthesis, cardiac fraction III cyclic nucleotide phosphodiesterase (PDE-III) inhibition, and positive inotropic activity of a series of 2(1H)-quinazolinones are reported.A general synthesis of the series involved the cyclization of 2-aminoacetophenones with potassium cyanate in acetic acid.Modifications at the 4-position of the quinazoline nucleus were best achieved by formation of the intermediate N1-acyl-N3-phenylurea from the substituted phenyl isocyanate and appropriate carboxamide.PPA was used to ring close to the quinazoline product.Generally the SAR for the series paralleled the five-point model previously published for PDE-III inhibition.The most active analogue of the series was 5,6-dimethoxy-4-methyl-2(1H)-quinazolinone (1) (ORF 16600), which had about twice the intravenous potency of amrinone.Compound 1 is currently under development as an orally active cardiotonic.
