60283-14-9

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-AMINO-5-PIPERIDINOPHENYL)-1-ETHAONE is used as a chemical intermediate for the synthesis of various pharmaceuticals, leveraging its structural components to create molecules with therapeutic effects. Its presence of a piperidine ring and an amino group provides versatility in chemical reactions, facilitating the development of new drugs.
Used in Drug Discovery:
In the field of drug discovery, 1-(2-AMINO-5-PIPERIDINOPHENYL)-1-ETHANONE is utilized as a building block for the creation of novel molecules with potential therapeutic applications. Its unique combination of functional groups allows for the design of compounds that can target specific biological pathways, making it valuable in the search for treatments for neurological disorders and cancer.
Used in Organic Chemistry Research:
1-(2-AMINO-5-PIPERIDINOPHENYL)-1-ETHANONE is also used in organic chemistry research to explore new synthetic pathways and reaction mechanisms. Its structural features make it an interesting subject for studies aimed at understanding and optimizing chemical reactions, potentially leading to more efficient and effective synthetic routes for pharmaceutical production.

InChI:InChI=1/C13H18N2O/c1-10(16)12-9-11(5-6-13(12)14)15-7-3-2-4-8-15/h5-6,9H,2-4,7-8,14H2,1H3

Upstream product

• 56915-86-7 2'-nitro-5'-(piperidin-1-yl)acetophenone 

Downstream Products

• 39911-01-8 3-(piperidin-1-yl)-acetophenone 

Relevant academic research and scientific papers

Synthesis and Cardiotonic Activity of a Series of Substituted 4-Alkyl-2(1H)-quinazolinones

The synthesis, cardiac fraction III cyclic nucleotide phosphodiesterase (PDE-III) inhibition, and positive inotropic activity of a series of 2(1H)-quinazolinones are reported.A general synthesis of the series involved the cyclization of 2-aminoacetophenones with potassium cyanate in acetic acid.Modifications at the 4-position of the quinazoline nucleus were best achieved by formation of the intermediate N1-acyl-N3-phenylurea from the substituted phenyl isocyanate and appropriate carboxamide.PPA was used to ring close to the quinazoline product.Generally the SAR for the series paralleled the five-point model previously published for PDE-III inhibition.The most active analogue of the series was 5,6-dimethoxy-4-methyl-2(1H)-quinazolinone (1) (ORF 16600), which had about twice the intravenous potency of amrinone.Compound 1 is currently under development as an orally active cardiotonic.

Novel antibacterial amide compounds and process means for producing the same

Novel organic amide compounds which are N-[6-[(substituted amino)phenyl]-1,2-dihydro-2-oxonicotinyl]penicillin and cephalosporin type compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or cephalosporin or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding N-6-[(substituted amino)phenyl]-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-amino-penicillanic acid, 7-aminocephalosporanic acid, 7-amino-3-methylceph-3-em-4-carboxylic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-[(substituted amino)phenyl]-1,2-dihydro-2-oxonicotinyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.