39911-01-8

Basic information

• Product Name: 1-(3-(Piperidin-1-yl)phenyl)ethanone
• Synonyms: 1-(3-(Piperidin-1-yl)phenyl)ethanone
• CAS NO: 39911-01-8
• Molecular Weight: 203.284
• Mol File: 39911-01-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(3-(Piperidin-1-yl)phenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-(Piperidin-1-yl)phenyl)ethanone(39911-01-8)
• EPA Substance Registry System: 1-(3-(Piperidin-1-yl)phenyl)ethanone(39911-01-8)

Safety Data

• Hazardous Substances Data: 39911-01-8(Hazardous Substances Data)

Usage

Class

Organic compound

Subclass

Ketones

Structural features

Contains a phenyl ring and a piperidine ring

Usage

Building block in the synthesis of various pharmaceuticals and biologically active molecules

Therapeutic applications

Antidepressant, anxiolytic agent

Potential as a modulator

Dopaminergic and serotonergic

Relevance

Interest in the development of new drugs for treating psychiatric disorders

Upstream product

• 110-89-4 piperidine 
• 56915-86-7 2'-nitro-5'-(piperidin-1-yl)acetophenone 
• 60283-14-9 2'-amino-5'-piperidinoacetophenone 
• 99-90-1 para-bromoacetophenone 
• 2142-63-4 1-(3-Bromophenyl)ethanone 

Downstream Products

• 56916-12-2 2-oxo-6-(3-piperidin-1-yl-phenyl)-1,2-dihydro-pyridine-3-carbonitrile 

Relevant articles and documents

A novel and unusual method for C[sbnd]N bond formation between benzene ring and various amines

A new approach to form C[sbnd]N bond without metal catalysis was developed. 4-acetylbenzoyl isocyanate reacted with various amines through a mild method to form C[sbnd]N bond. This reaction was amenable to scale-up and it afforded the corresponding products with good to excellent yields and tolerates a wide range of functional groups.

Amination of aryl bromides catalysed by supported palladium

Palladium particles immobilised onto a metal oxide support or Pd(0), Pd(II) and [Pd(NH3)4]2+ in NaY zeolite have been prepared and characterised. They exhibit a good activity towards the amination of aryl bromides using secondary amines such as piperidine and diethyl amine with a good regio-selectivity for these reactions. Low Pd concentrations (1 mol%) are required to observe a reasonable regio-selectivity. The catalysts can easily be separated from the reaction mixture (filtration) and reused without loss of activity and selectivity. The electronic nature of the aryl halides plays an important role for both the reaction yields and the regio-control of the reaction. It depends on the relation of the direct amination via a benzyne intermediate versus the Pd-catalysed route.