6029-25-0Relevant academic research and scientific papers
Crystal structures, packing features, Hirshfeld surface analyses and DFT calculations of hydrogenbond energy of two homologous 8a-aryl- 2,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrimidin- 6(1H)-ones
Dmitriev, Maksim V.,Grinev, Vyacheslav S.,Krainov, Mikhail N.,Linkova, Elena I.,Yegorova, Alevtina Yu.
, p. 483 - 489 (2020/05/18)
The crystal structures and packing features of two homologous Meyer's bicyclic lactams with fused pyrrolidone and medium-sized perhydropyrimidine rings, namely, 8a-phenyl-2,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrimidin-6(1H)-one, C13H16N2O (1), and 8a-(4-methylphenyl)-2,3,4,7,8,8a-hexahydropyrrolo[1,2-a]- pyrimidin-6(1H)-one, C14H18N2O (2), were elucidated, and Hirshfeld surface plots were calculated and drawn for visualization and a deeper analysis of the intermolecular noncovalent interactions. Molecules of 1 and 2 are weakly linked by intermolecular C O H N hydrogen bonds into chains, which are in turn weakly linked by other C O H Car interactions. The steric volume of the substituent significantly affects the crystal packing pattern..
Polycyclic amino derivatives of pyrrolidone and piperidone
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, (2008/06/13)
A series of compounds of the formula STR1 have been found to exhibit useful pharmacological properties, e.g. antiinflammatory and analgetic activity.
