60290-49-5

Upstream product

• 137-07-5 2-amino-benzenethiol 
• 93-91-4 1-phenylbutan-1,3-dione 
• 50783-26-1 1-(2-methyl-2,3-dihydrobenzothiazol-2-yl)-methyl phenyl ketone 
• 63289-96-3 (Z)-3-hydroxy-1-phenyl-but-2-en-1-one 
• 923001-76-7 C₁₄H₁₉NO 
• 1141-88-4 2-Aminophenyl disulfide 
• 39159-64-3 3-anilino-1-phenyl-2-buten-1-one 

Relevant academic research and scientific papers

Novel synthesis of 1,4-benzothiazines in water accelerated by β-cyclodextrin

Novel one-pot synthetic protocol has been developed for obtaining 2, 3-disubstituted 1,4-benzothiazines with excellent yields, carrying cyclocondensation of 1,3-dicarbonyl compounds with substituted 2-(2-(2-aminophenyl)disulfanyl)benzenamines, under supra

Graphene oxide (GO): An efficient carbocatalyst for the benign synthesis of functionalized 1,4-benzothiazines

Graphene oxide (GO) has been found to be highly efficient and recyclable carbocatalyst for the benign construction of heterocyclic molecule 1,4-benzothiazine from 2-aminothiophenol and 1,3-dicarbonyl compound. A vast range of highly functionalized 1,4-ben

Baker's yeast catalyzed synthesis of 1,4-benzothiazines, performed under ultrasonication

An efficient and simple one pot method has been developed for the synthesis of 1,4-benzothiazines by allowing the condensation of 2-aminobenzenethiols and 1,3-dicarbonyls using cheaper biocatalyst, baker's yeast. The role of ultrasonication in the rate expediting of the condensation has been discussed.

One-pot multi-component approach to the synthesis of 1,4-benzothiazines in aqueous media

A new and rapid synthetic strategy for the oxidative cyclocondensation of 2-aminobenzenethiol and 1,3-dicarbonyls has been developed in order to obtain 2,3-disubstituted 1,4-benzothiazines at ambient temperature and in aqueous media. A mechanism is presen

Nucleophilic addition of enaminones to the S-S dimer of 2-aminobenzenethiol

Nucleophilic addition of β-amino α,β-unsaturated ketones and esters to the S-S dimer of 2-aminobenzenethiol which acts as an electrophile, followed by cyclization, lead to 4H-1,4-benzothiazine derivatives. ARKAT.

Synthesis of a series of 2,3-disubstituted 4H-1,4-benzothiazines and X-ray crystal structure of ethyl 7-chloro-3-methyl-4H-1,4-benzothiazine-2-carboxylate

The reaction between 2-aminobenzenethiol and ethyl acetoacetate is studied under a variety of conditions, and a procedure for the exclusive synthesis of 1,4-benzothiazines by the neat reaction of substituted aminothiols with β-ketoesters and β-dicarbonyl compounds in 85-96% yield is described. With microwave heating, even when both the reactants are solid, yields are high, reaction times brief, and work-up easy. A facile reaction is also observed even in a solid-state reaction. The molecular structure of ethyl 7-chloro-3-methyl-4H-1,4-benzothiazine-2-carboxylate (4d) was determined by single-crystal X-ray diffraction.

Ligand exchange reactions of NiCl2(PPh3)2 with O(S)∩N∩S ligands

Ligand exchange reactions of NiCl2(PPh3)2 with O(S)∩N∩S ligands were studied. Oxidation products of O∩N∩S ligands have been characterized and their structures determined: 3-methyl-4H-benzo[b][1,4]thiazin-2-yl-phenylmethanone / 2-methyl-benzo[d][1,3]thiazole (mixed crystal); [2-iminoisopropyl-thiophenolato(2-)](triphenyl-phosphane)-nickel(II); 1-phenyl-3-methyl-4-(benzoyl-thiobenzoylhydrazono)-pyrazol-5-thione; [1-phenyl-3-methyl-4-(benzoyl-thiobenzoylhydrazono)-pyrazol-5-thionato] (triphenyl-phosphane)-nickel(II).

Reaction Products of 2-Aminobenzenethiol with some β-Diketones

2-Aminobenzenethiol undergoes condensation reactions with several β-diketones (CH3, CF3 and C6H5 substituents) to form benzothiazolines.Conversion to benzothiazines and benzothiazoles occurs in some instances, as documented by isolation and spectroscopic characterization of the products.