60301-20-4

Basic information

• Product Name: 1-methyl-1H-indazol-3-amine
• Synonyms: 1-methyl-1h-indazol-3-amine;1-methyl-1H-indazol-3-amine(SALTDATA: FREE)
• CAS NO: 60301-20-4
• Molecular Formula: C₈H₉N₃
• Molecular Weight: 147.18
• Mol File: 60301-20-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 85-88°
• Boiling Point: 321.614°C at 760 mmHg
• Flash Point: 148.307°C
• Appearance: White to pale brown/Crystalline Powder
• Density: 1.273g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.667
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.96±0.50(Predicted)
• CAS DataBase Reference: 1-methyl-1H-indazol-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-1H-indazol-3-amine(60301-20-4)
• EPA Substance Registry System: 1-methyl-1H-indazol-3-amine(60301-20-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 60301-20-4(Hazardous Substances Data)

Usage

General Description

1-methyl-1H-indazol-3-amine is a chemical compound with the molecular formula C9H9N3. It belongs to the indazole class of compounds and is derived from the parent structure of indazole. 1-methyl-1H-indazol-3-amine is a derivative of 1H-indazole-3-amine, with a methyl group attached to the nitrogen atom. It is used in organic synthesis and pharmaceutical research as a building block for the creation of various pharmaceutical and biologically active compounds. This chemical has potential applications in the development of new drugs and is of interest to researchers in the fields of medicinal chemistry and drug discovery.

InChI:InChI=1/C8H9N3/c1-11-7-5-3-2-4-6(7)8(9)10-11/h2-5H,1H3,(H2,9,10)

Upstream product

• 13436-48-1 1-methyl-1H-indazole 
• 874-05-5 3-aminoindazole 
• 394-47-8 2-fluorobenzonitrile 
• 365427-30-1 4-bromo-1-methyl-1H-indazole 
• 1073-06-9 3-fluorobromobenzene 
• 360575-28-6 2-bromo-6-fluorobenzaldehyde 
• 60-34-4 methylhydrazine 
• 82575-23-3 2-(1H-indazol-3-yl)isoindoline-1,3-dione 
• 113385-39-0 2-(1-Methyl-1H-indazol-3-yl)-isoindole-1,3-dione 

Downstream Products

• 13436-48-1 1-methyl-1H-indazole 

Relevant articles and documents

A method for the regioselective synthesis of 1-alkyl-1H-indazoles

A method for the regioselective synthesis of 3-unsubstituted 1-alkyl-1H-indazoles, starting with 2-halobenzonitriles and N-alkylhydrazines, is described. The two-step reaction pathway proceeds through the intermediacy of 1-alkyl-3-amino-1H-indazoles follo

A general, one-step synthesis of substituted indazoles using a flow reactor

Flow chemistry is a rapidly emerging technology within the pharmaceutical industry, both within medicinal and development chemistry groups. The advantages of flow chemistry, increased safety, improved reproducibility, enhanced scalability, are readily apparent, and we aimed to exploit this technology in order to provide small amounts of pharmaceutically interesting fragments via a safe and scalable route, which would enable the rapid synthesis of multigram quantities on demand. Here we report a general and versatile route which utilises flow chemistry to deliver a range of known and novel indazoles, including 3-amino and 3-hydroxy analogues.