60301-88-4

Usage

InChI:InChI=1/C22H34N2O6.Na/c25-20-16-15-18(24(29)30)17-19(20)23-21(26)13-11-9-7-5-3-1-2-4-6-8-10-12-14-22(27)28;/h15-17,25H,1-14H2,(H,23,26)(H,27,28);/q;+1/p-1

Upstream product

• 60301-87-3 2'-hydroxy-5'-nitrohexadecananilide 

Relevant academic research and scientific papers

Synthesis of 2-alkanoylamino-4-nitrophenyl phosphorylcholine-hydroxide

A method for synthesizing a 2-alkanoylamino-4-nitrophenyl phosphorylcholine-hydroxide useful as a sphingomyelinase-specific chromogenic artificial substrate in the diagnostic testing for Niemann-Pick disease. The method comprises reacting 2-amino-4-nitrophenol with an alkanoyl halide to form the alkananilide; phosphorylating the alkali phenolate salt of the alkananilide with β-bromoethylphosphoryl dichloride to form a mixture of mono- and di-alkananilide phosphoric acid esters; recovering from the mixture the mono-alkananilide phosphoric acid ester and quaternizing it with trimethylamine; and treating the resulting quaternary salt with a mixture of weak acidic and weak basic ion exchange resins to convert it into the 2-alkanoylamino-4-nitrophenyl phosphoryl-choline-hydroxide.