603040-23-9

Upstream product

• 84608-35-5 2-((4S,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 1200831-33-9 C₂₅H₃₄O₃Si 
• 791101-25-2 {(4R,5S)-5-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol 

Downstream Products

• 957206-99-4 C₄₅H₅₃F₁₃O₆Si 
• 603038-90-0 C₃₇H₄₈O₆Si 
• 1200831-59-9 C₂₆H₃₆O₄Si 
• 1201850-57-8 C₄₃H₅₁F₉O₆Si 
• 1201850-58-9 C₄₆H₄₉F₁₇O₆Si 

Relevant academic research and scientific papers

IRREVERSIBLE INHIBITORS USEFUL FOR THE TREATMENT OF KINASE-RELATED PATHOLOGIES

The present invention provides new compounds (I) having a kinase inhibitory activity and useful for treating cancer.

Compositions And Methods Comprising Analogues Of Radicicol A

Disclosed are novel analogues of the natural product radicicol A of formulae I, .Ia, pi, Ha, lib and HI, pharmaceutical compositions comprising the compounds. The compounds of the invention are kinase and phosphatase inhibitors and find utility in the tre

Divergent syntheses of resorcylic acid lactones: L-783277, LL-Z1640-2, and hypothemycin

The resorcylic acid lactones (RAL) are endowed with diverse biological activity ranging from transcription factor modulators (zearalenone and zearalenol) to HSP90 inhibitors (radicicol and pochonin D) and reversible (aigialomycin D) as well as irreversibl

Synthesis of a Resorcylic Acid Lactone (RAL) library using fluorous-mixture synthesis and profile of its selectivity against a panel of kinases

A library of resorcylic acid lactones (RAL) containing a cis-enone moiety targeting kinases bearing a cysteine residue within the ATP-binding pocket was prepared using a fluorous-mixture synthesis and evaluated against a panel of 19 kinases thus providing important structure-activity trends. Two new analogues were then profiled for their selectivity against a panel of 402 kinases providing the broadest evaluation of this pharmacophores' selectivity.

Modular synthesis of radicicol A and related resorcylic acid lactones, potent kinase inhibitors

(Chemical Equation Presented) Short and sweet: A concise and modular synthesis of radicicol A and related resorcylic acid lactones using fluorous isolation technology and immobilized reagents is reported (see scheme, R F = C3H6

MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS

The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1 -R11, t, X, Y, Z, and n are as defined herein.