603041-29-8

Upstream product

• 474711-11-0 2-bromo-4-fluoro-1-(methoxymethoxy)benzene 
• 68-12-2 N,N-dimethyl-formamide 
• 347-54-6 5-fluoro-2-hydroxybenzaldehyde 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 603041-30-1 C₉H₉FO₃ 

Relevant academic research and scientific papers

MACROCYCLES FOR TREATING DISEASE

The present disclosure relates to certain macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat disease, such as cancer. Also provided are methods of inhibiting receptor tyrosine kinases such as RET or SRC using the macrocyclic derivatives. The macrocyclic compounds have a tetracyclic heterocyclic core moiety, such as, cylopenta[5,6][1,4]oxazino[3,4-j] pyrazolo[4,3-g][1,5,9,11]benzoxatriazacyclotetradecin-15-one.

MACROCYCLES FOR USE IN TREATING DISEASE

The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer, pain, neurological diseases, autoimmune diseases, and inflammation.

MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS

The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1 -R11, t, X, Y, Z, and n are as defined herein.