60308-65-8Relevant academic research and scientific papers
MRGX Receptor Antagonists
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Paragraph 0410-0412, (2021/05/07)
The invention relates to a method for preventing or treating a disease or disorder that is associated with the MrgX2 receptor. The invention also relates to MrgX2 antagonists and physiologically acceptable salts thereof. The invention also relates to pharmaceutical compositions and dosage forms comprising an MrgX2 antagonist.
New modified 2-aminobenzimidazole nucleosides: Synthesis and evaluation of their activity against herpes simplex virus type 1
Kharitonova, Maria I.,Denisova, Alexandra O.,Andronova, Valeria L.,Kayushin, Alexei L.,Konstantinova, Irina D.,Kotovskaya, Svetlana K.,Galegov, Georgiy A.,Charushin, Valery N.,Miroshnikov, Anatoly I.
supporting information, p. 2484 - 2487 (2017/05/10)
Using the enzymatic transglycosylation reaction β-D-ribo- and 2′-deoxyribofuranosides of 2-amino-5,6-difluorobenzimidazole nucleosides have been synthesized. 2-Amino-5,6-difluoro-benzimidazole riboside proved to exhibit a selective antiviral activity (selectivity index >32) against a wild strain of the herpes simplex virus type 1, as well as towards virus strains that are resistant to acyclovir, cidofovir, and foscarnet. We believe that this compound might be used for treatment of herpes infections in those cases, when acyclovir is not efficient.
A new synthesis of amino substituted azolo[1,3,5]triazines via reaction of N1,N1-dimethyl-N2-azolylformamidines with cyanamide
Kalinin, Dmitrii V.,Kalinina, Svetlana A.,Dolzhenko, Anton V.
, p. 147 - 154 (2013/03/13)
The amino substituted triazine ring was annelated to aminoazoles using a new effective synthetic procedure. The method of preparation involved initial formation of azolylformamidines in the reaction of aminoazoles with N,N-dimethylformamide dimethyl acetal followed by the triazine ring closure with cyanamide affording therefore fused aminotriazines.
