603126-64-3

Upstream product

• 4144-62-1 5-benzoylvaleric acid 
• 870262-28-5 1-imidazol-1-yl-6-phenyl-hexane-1,6-dione 
• 75-77-4 chloro-trimethyl-silane 
• 21876-11-9 6-oxo-6-phenyl-hexanoic acid methyl ester 

Downstream Products

• 4829-02-1 2-hydroxy-2-phenylcyclohexanone 

Relevant academic research and scientific papers

Electroreductive intramolecular coupling of aromatic δ- and ε-keto esters

Electroreduction of aromatic δ- and ε-keto esters in the presence of chlorotrimethylsilane and triethylamine gave five- and six-membered cyclized products. The products were transformed to the corresponding α-hydroxy ketones.

Electroreductive acylation of aromatic ketones with acylimidazoles

The intermolecular reductive coupling of aromatic ketones with acylimidazoles was effected by electroreduction in the presence of chlorotrimethylsilane and gave α-trimethylsiloxy ketones and esters. The best result was obtained using Bu4NPF6 as a supporting electrolyte and a Pb cathode in THF. The α-trimethylsiloxy-containing products were transformed to the corresponding α-hydroxy ketones and esters by treatment with TBAF in THF. This method was also effective for the intramolecular reductive coupling of δ- and ε-keto acylimidazoles.