603128-17-2

Upstream product

• 40890-47-9 2-benzyl-4-chloro-5-methoxy-2H-pyridazin-3-one 
• 603128-14-9 2-benzyl-4-phenyl-5-trifluoromethanesulfonyloxypyridazin-3(2H)-one 
• 603128-19-4 N-[2-(2-benzyl-3-oxo-4-phenyl-2,3-dihydropyridazin-5-yl)phenyl]pivalamide 
• 603128-13-8 2-benzyl-5-hydroxy-4-phenylpyridazin-3(2H)-one 
• 603128-12-7 2-benzyl-5-methoxy-4-phenylpyridazin-3(2H)-one 
• 603128-15-0 2-benzyl-5-(2-bromophenyl)-4-phenylpyridazin-3(2H)-one 
• 603128-20-7 5-(2-aminophenyl)-2-benzyl-4-phenylpyridazin-3(2H)-one 

Relevant academic research and scientific papers

Pd-catalyzed intramolecular direct arylations at high temperature

Pd-catalyzed cyclodehydrohalogenation involving oxidative addition of aromatic C-Br or activated azaheteroaromatic C-Cl bonds and C(sp2)-H activation have been investigated at high reaction temperatures (180-200 °C). This allowed the fast (10-3

Synthesis of the dibenzo[f,h]phthalazine and dibenzo[f,h]cinnoline skeleton via a 'Suzuki-Pd-catalyzed intramolecular arylation' and a 'Suzuki-Pschorr' approach

Palladium-catalyzed intramolecular arylation of 2-benzyl-5-(2-bromophenyl)-4-phenylpyridazin-3(2H)-one yielded hitherto unknown 2-benzyldibenzo[f,h]phthalazin-1(2H)-one. The synthesis of this new tetracyclic pyridazinone from 2-benzyl-5-(2-aminophenyl)-4-phenylpyridazin-3(2H)-one via a Pschorr type reaction was also investigated. Similarly, the construction of 2-methyldibenzo[f,h]cinnolin-3(2H)-one from 2-methyl-5-(2-bromophenyl)-6-phenylpyridazin-3(2H)-one and 2-methyl-5-(2-aminophenyl)-6-phenylpyridazin-3(2H)-one is also reported. Removal of the N-benzyl protective group of 2-benzyl-dibenzo[f,h]phthalazin-1(2H)-one with AlCl3 yielded unsubstituted dibenzo[f,h]phthalazin-1(2H)-one.