40890-47-9

Usage

Uses

Used in Pharmaceutical Industry:
2-BENZYL-4-CHLORO-5-METHOXY-3(2H)-PYRIDAZINONE is used as an anti-inflammatory agent for its ability to reduce inflammation in experimental models.
Used in Oncology:
2-BENZYL-4-CHLORO-5-METHOXY-3(2H)-PYRIDAZINONE is used as an anti-cancer agent for its potential to inhibit the growth of certain cancer cells.
Used in Antifungal Applications:
2-BENZYL-4-CHLORO-5-METHOXY-3(2H)-PYRIDAZINONE is used as an antifungal agent for its potential to combat fungal infections.
Used in Antiviral Applications:
2-BENZYL-4-CHLORO-5-METHOXY-3(2H)-PYRIDAZINONE is used as an antiviral agent for its potential to treat viral infections.
Further research is needed to fully understand the pharmacological properties and potential uses of 2-BENZYL-4-CHLORO-5-METHOXY-3(2H)-PYRIDAZINONE in various industries.

InChI:InChI=1/C12H11ClN2O2/c1-17-10-7-14-15(12(16)11(10)13)8-9-5-3-2-4-6-9/h2-7H,8H2,1H3

Upstream product

• 124-41-4 sodium methylate 
• 41933-33-9 2-benzyl-4,5-dichloro-3(2H)-pyridazinone 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 67-56-1 methanol 
• 932-22-9 4,5-dichloro-2H-pyridazin-3-one 

Downstream Products

• 938045-28-4 2-benzyl-5-methoxy-4-methylpyridazin-3(2H)-one 
• 476172-04-0 2-benzyl-pyridazino[4,5-c]isoquinolin-1(2H)-one 
• 603128-19-4 N-[2-(2-benzyl-3-oxo-4-phenyl-2,3-dihydropyridazin-5-yl)phenyl]pivalamide 
• 603128-14-9 2-benzyl-4-phenyl-5-trifluoromethanesulfonyloxypyridazin-3(2H)-one 
• 603128-15-0 2-benzyl-5-(2-bromophenyl)-4-phenylpyridazin-3(2H)-one 
• 603128-20-7 5-(2-aminophenyl)-2-benzyl-4-phenylpyridazin-3(2H)-one 
• 603128-17-2 2-benzyl-dibenzo[f,h]phthalazin-1(2H)-one 
• 603128-13-8 2-benzyl-5-hydroxy-4-phenylpyridazin-3(2H)-one 
• 938045-32-0 3-benzylbenzo[f]phthalazin-4(3H)-one 
• 938045-31-9 2-benzyl-5-(2-formylphenyl)-4-methylpyridazin-3(2H)-one 
• 938045-30-8 C₁₂H₁₁ON₂OCF₃SO₂ 
• 938045-29-5 2-benzyl-5-hydroxy-4-methylpyridazin-3(2H)-one 
• 929190-96-5 2-benzyl-5-propyl-2,5-dihydro-pyridazino[4,5-b]indol-1-one 
• 929190-93-2 2-benzyl-2,5-dihydro-pyridazino[4,5-b]indol-1-one 

Relevant academic research and scientific papers

Synthesis of Novel Pyridazino[4,5-b][1,4]oxazine-3,5-diones

Novel pyridazino[4,5-b][1,4]oxazine-3,5-diones were synthesized from N-[2-(3,4-dimethoxyphenyl)-ethyl]-2-chloroacetamide (or 2-chloropropanamide) and 1-alkyl-5-halo-4-hydroxypyridazin-6-ones in good yield.

Azabicyclic heterocycles as cannabinoid receptor modulators

The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the general Formula I: including all prodrugs, pharmaceutically acceptable salts and stereoisomers, R1, R2, R3, R6, R7, m and n are described herein.

Synthesis of the dibenzo[f,h]phthalazine and dibenzo[f,h]cinnoline skeleton via a 'Suzuki-Pd-catalyzed intramolecular arylation' and a 'Suzuki-Pschorr' approach

Palladium-catalyzed intramolecular arylation of 2-benzyl-5-(2-bromophenyl)-4-phenylpyridazin-3(2H)-one yielded hitherto unknown 2-benzyldibenzo[f,h]phthalazin-1(2H)-one. The synthesis of this new tetracyclic pyridazinone from 2-benzyl-5-(2-aminophenyl)-4-phenylpyridazin-3(2H)-one via a Pschorr type reaction was also investigated. Similarly, the construction of 2-methyldibenzo[f,h]cinnolin-3(2H)-one from 2-methyl-5-(2-bromophenyl)-6-phenylpyridazin-3(2H)-one and 2-methyl-5-(2-aminophenyl)-6-phenylpyridazin-3(2H)-one is also reported. Removal of the N-benzyl protective group of 2-benzyl-dibenzo[f,h]phthalazin-1(2H)-one with AlCl3 yielded unsubstituted dibenzo[f,h]phthalazin-1(2H)-one.

Synthesis of 4-aryl-5-hydroxy- and 5-aryl-4-hydroxypyridazin-3(2H)-ones and their use in the preparation of 4,5-diarylpyridazin-3(2H)-ones and hitherto unknown isochromeno[3,4-d]pyridazinediones

Easily accessible 2-substituted 4-aryl-5-methoxy- and 2-substituted 5-aryl-4-methoxypyridazin-3(2H)-ones were transformed into the corresponding aryl-hydroxypyridazin-3(2H)-ones by alkaline hydrolysis. The use of these compounds in the synthesis of 2-substituted 4,5-diarylpyridazin-3(2H)-ones with two differently substituted aryl groups was investigated. Two aryl-hydroxypyridazin-3(2H)-ones, 2-(2-benzyl-5-hydroxy-3-oxo-2,3-dihydropyridazin-4-yl)benzaldehyde and 2-(1-benzyl-5-hydroxy-6-oxo-1,6-dihydropyridazin-4-yl)benzaldehyde, were transformed into 2-benzyl-1H-isochromeno[3,4-d]pyridazine-1,6(2H)-dione and 3-benzyl-3H-isochromeno[3,4-d]pyridazine-4,6-dione, respectively, via oxidation of the formyl group with KMnO4 followed by lactonization.

Synthesis of new pyridazino[4,5-c]isoquinolinones by Suzuki cross-coupling reaction

Suzuki cross-coupling reaction of 2-alkyl(methyl and benzyl)-5-chloro-4-methoxy- and 2-alkyl(methyl and benzyl)-4-chloro-5-methoxypyridazin-3(2H)-ones with 2-formylphenylboronic acid afforded the corresponding biaryl products which were cyclized with ammonia to yield hitherto undescribed pyridazino[4,5-c]isoquinolinones. Removal of the N-benzyl protective group in position 2 yielded the unsubstituted tricyclic pyridazinones.