603130-25-2 Usage
Uses
Used in Pharmaceutical Industry:
2,6-Anhydro-3,4,5-trideoxy-5-[[(1,1-dimethylethoxy)carbonyl]amino]-D-threo-hexonic Acid is used as a key intermediate in the synthesis of tetrahydropyran-based dipeptide isoteres. These compounds have shown potential as topoisomerase inhibitors, which are crucial in the development of novel therapeutic agents for various diseases, including cancer.
In the synthesis of tetrahydropyran-based dipeptide isoteres, 2,6-Anhydro-3,4,5-trideoxy-5-[[(1,1-diMethylethoxy)carbonyl]aMino]-D-threo-hexonic Acid serves as a valuable building block due to its unique structural features. The presence of the anhydro ring and the deoxygenated carbons at specific positions allows for the formation of complex molecular architectures that can interact with biological targets, such as topoisomerases, in a highly specific manner. This interaction can lead to the inhibition of these enzymes, which play a critical role in DNA replication and transcription, and are often overexpressed in cancer cells.
Furthermore, the (1,1-dimethylethoxy)carbonyl group attached to the amino function provides additional opportunities for chemical modification and functionalization, enabling the development of more potent and selective inhibitors. 2,6-Anhydro-3,4,5-trideoxy-5-[[(1,1-diMethylethoxy)carbonyl]aMino]-D-threo-hexonic Acid's role in the synthesis of topoisomerase inhibitors highlights its importance in the pharmaceutical industry, where the development of new and effective drugs is of utmost importance.
Check Digit Verification of cas no
The CAS Registry Mumber 603130-25-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,0,3,1,3 and 0 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 603130-25:
(8*6)+(7*0)+(6*3)+(5*1)+(4*3)+(3*0)+(2*2)+(1*5)=92
92 % 10 = 2
So 603130-25-2 is a valid CAS Registry Number.
603130-25-2Relevant academic research and scientific papers
Synthesis of novel tetrahydropyran-based dipeptide isosters by overman rearrangement of 2,3-didehydroglycosides
Kriek, Nicole M. A. J.,Van der Hout, Elise,Kelly, Paskal,Van Meijgaarden, Krista E.,Geluk, Annemieke,Ottenhoff, Tom H. M.,Van der Marel, Gijs A.,Overhand, Mark,Van Boom, Jacques H.,Valentijn, A. Rob P. M.,Overkleeft, Herman S.
, p. 2418 - 2427 (2007/10/03)
Differently functionalized tetrahydropyran-based dipeptide isosters have been efficiently synthesized from 3,4,6-tri-Oacetyl-D-glucal. Analogues of the hsp65 p2-13 epitope of Mycobacterium tuberculosis and Mycobacterium leprae were prepared by replacement of the Ala-Tyr or Glu-Glu moiety in the native dodecapeptide with the prepared dipeptide isosters. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
