60316-45-2Relevant academic research and scientific papers
Facile Synthesis of Functionalized 1,4-Benzodiazepine-3-One-5-Acetates via [4 + 3]-Annulation of Azaoxyallyl Cations With 2-Aminophenyl α,β-Unsaturated Esters
Jang, Hyun Sun,Kim, Sung-Gon,Kwon, Yong Il
, (2020)
A metal-free [4 + 3]-annulation of α-halohydroxamates with 2-aminophenyl α,β-unsaturated esters has been developed for the construction of seven-membered 1,4-benzodiazepine-3-one-5-acetates in moderate to good yields (up to 82% yield). The annulation invo
Organocatalytic Aza-Michael/Michael Cyclization Cascade Reaction: Enantioselective Synthesis of Spiro-oxindole Piperidin-2-one Derivatives
Tang, Qing-Gang,Cai, Sen-Lin,Wang, Chuan-Chuan,Lin, Guo-Qiang,Sun, Xing-Wen
supporting information, p. 3351 - 3355 (2020/04/21)
A simple, direct, and highly enantioselective synthesis of spiro-oxindole piperidin-2-one derivatives was achieved through an aza-Michael/Michael cyclization cascade sequence using a squaramide catalyst. The desired products were obtained in excellent yields (up to 99%) and good to high stereoselectivities (up to >20:1 dr and up to 99% ee) under mild conditions.
Direct N- sec -Alkylation of Amides by Reaction of α-Halohydroxamates and Sulfonylindoles: An Approach to 3-Indolyl Methanamines
Chen, Yuan,Guo, Xiaoqiang,Zhou, Chuang,Chen, Lianmei,Kang, Tairan
supporting information, p. 851 - 856 (2019/04/25)
A catalyst-free, base-mediated N- sec -alkylation of amides by reaction of sulfonylindoles and α-halohydroxamates has been developed. The N- sec -alkylation of amides reaction is based on an intermolecular nucleophilic addition of vinylogous imine with N
NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING THE SAME
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Page/Page column 9; 10, (2012/11/07)
The present invention relates to 7-membered nitrogen-containing heterocyclic compounds and methods of making the same. Using a novel aza-[4+3] cycloaddition reaction, the 7-membered heterocyclic compounds are synthesized by reacting a first reactant and a second reactant. Exemplary first reactants and second reactants include α-halohydroxamates and dienes, respectively.
Generation and reactivity of aza-oxyallyl cationic intermediates: Aza-[4 + 3] cycloaddition reactions for heterocycle synthesis
Jeffrey, Christopher S.,Barnes, Korry L.,Eickhoff, John A.,Carson, Christopher R.
, p. 7688 - 7691 (2011/07/06)
Aza-[4 + 3] cycloadditions of putative aza-oxyallyl cationic intermediates and cyclic dienes are reported. The intermediate is generated by the dehydrohalogenation of α-haloamides. The reaction is general to a variety of α-haloamides and is diastereoselective. Computational and experimental data suggest that an N-alkoxy substituent stabilizes the aza-oxyallyl cationic intermediate.
Samarium iodobinaphtholate: An efficient catalyst for enantioselective aza-michael additions of O-benzylhydroxylamine to N-alkenoyloxazolidinones
Didier, Dorian,Meddour, Abdelkrim,Bezzenine-Lafollee, Sophie,Collin, Jacqueline
experimental part, p. 2678 - 2684 (2011/06/25)
Samarium diiodide is an efficient catalyst for the aza-Michael addition of O-benzylhydroxylamine to α,β-unsaturated N-acyloxazolidinones leading to mixtures of the Michael adduct and the product resulting from its amidation. Samarium iodobinaphtholate cat
