1303507-75-6Relevant academic research and scientific papers
Direct N- sec -Alkylation of Amides by Reaction of α-Halohydroxamates and Sulfonylindoles: An Approach to 3-Indolyl Methanamines
Chen, Yuan,Guo, Xiaoqiang,Zhou, Chuang,Chen, Lianmei,Kang, Tairan
, p. 851 - 856 (2019)
A catalyst-free, base-mediated N- sec -alkylation of amides by reaction of sulfonylindoles and α-halohydroxamates has been developed. The N- sec -alkylation of amides reaction is based on an intermolecular nucleophilic addition of vinylogous imine with N
Base-Mediated [3 + 4]-Cycloaddition of Anthranils with Azaoxyallyl Cations: A New Approach to Multisubstituted Benzodiazepines
Feng, Juan,Zhou, Meng,Lin, Xuanzi,Lu, An,Zhang, Xiaoyi,Zhao, Ming
, p. 6245 - 6248 (2019)
A new [3 + 4] cycloaddition of azaoxyallyl cations and anthranils has been achieved for rapid access to multisubstituted benzodiazepine derivatives. A variety of anthranils and α-halo hydroxamates were both effective substrates with simple operations unde
Synthesis of 2-Aminoimidazolones and Imidazolones by (3 + 2) Annulation of Azaoxyallyl Cations
DiPoto, Maria C.,Wu, Jimmy
, p. 499 - 501 (2018)
The first examples of (3 + 2) annulations between azaoxyallyl cations and cyanamides and nitriles to give the corresponding 2-aminoimidazolones and imidazolones are reported. On the basis of the isolation of unexpected imidate products with certain substr
Cycloaddition Reaction of in Situ Formed Azaoxyallyl Cations with Aldehydes: An Approach to Oxazolidin-4-ones
Zhang, Kaifan,Yang, Chi,Yao, Hequan,Lin, Aijun
, p. 4618 - 4621 (2016)
A novel [3 + 2] cycloaddition reaction between in situ formed azaoxyallyl cations and aldehydes has been developed. This concise method allows the rapid formation of a number of oxazolidin-4-ones in high yields with good functional group tolerance at room temperature. Further transformation and late-stage modifications of drug molecules could also be achieved in good yields, highlighting the potential utility of the reaction.
Efficient one-pot synthesis of 1,3-dihydro-2H-pyrrol-2-one derivatives via aza-oxyallylic cations
Wang, Gangqiang,Chen, Rongxing,Wu, Minghu,Sun, Shaofa,Luo, Xing,Chen, Zhi,Guo, Haibing,Chong, Carlos,Xing, Yalan
, p. 847 - 850 (2017)
An efficient synthesis of functionalized 1,3-dihydro-2H-pyrrol-2-one was developed based on a [3+2] cycloaddition reaction of aza-oxyallylic cations and alkynes. With this novel method, a variety of substituted alkynes were readily converted into their co
Synthesis, Characterization of Spirocyclic λ3-Iodanes and Their Application to Prepare 4,1-Benzoxazepine-2,5-diones and 1,3-Diynes
Sun, Xu,Guo, Xiao-Qiang,Chen, Lian-Mei,Kang, Tai-Ran
supporting information, p. 4312 - 4316 (2021/02/06)
Herein, a [3+2] cycloaddition of aza-oxyallylic cations with ethynylbenziodoxolones for synthesis of new λ3-iodanes containing spirocyclic 4-oxazolidinone has been developed. This cyclic λ3-iodanes display stability in air and excellent solubility in organic solvent. Using them as substrate, both the 4,1-benzoxazepine-2,5-diones and symmetrical 1,3-diynes derivatives were afforded in high yield under copper(I)-catalyzed conditions.
An efficient synthesis of oxazolines: Via a cascade reaction between azaoxyallyl cations and 1,2-benzisoxazoles
Sun, Li,Liu, Yi,Wang, Yankai,Li, Yuanyuan,Liu, Zhiwen,Lu, Tao,Li, Wenhai
supporting information, p. 7526 - 7530 (2019/08/20)
A formal [3 + 2] cycloaddition reaction between the C and O terminals of azaoxyallyl cations formed in situ and 1,2-benzisoxazoles has been realized. This one-pot cycloaddition method provided an effective and practical pathway to synthesize oxazoline in good yields under mild conditions. The title products exhibited unique fluorescence properties.
Regio- and Diastereoselective Access to 4-Imidazolidinones via an Aza-Mannich Initiated Cyclization of Sulfamate-Derived Cyclic Imines with α-Halo Hydroxamates
Zhou, Jing,Zhang, Hong,Chen, Xue-Lian,Qu, Ya-Li,Zhu, Qianqian,Feng, Chen-Guo,Chen, Ya-Jing
, p. 9179 - 9187 (2019/08/12)
An efficient regio- and diastereoselective cyclization of sulfamate-derived cyclic imines with unsubstituted or monosubstituted α-halo hydroxamates is developed under mild conditions. This reaction proceeds smoothly under transition-metal-free conditions via a domino aza-Mannich addition/intramolecular nucleophilic substitution sequence, providing a convenient route to access 2-monosubstituted and 2,5-disubstituted 4-imidazolidinones. Notably, the products were obtained with single trans-isomers in moderate to excellent yields.
Synthesis of spirobarbiturate-pyrrolidinones: Via a domino aza-Michael/SN2 cyclization of barbiturate-derived alkenes with N-alkoxy α-haloamides
Wang, Chuan-Chuan,Zhou, Jing,Ma, Zhi-Wei,Chen, Xiao-Pei,Chen, Ya-Jing
supporting information, p. 9200 - 9208 (2019/11/05)
A highly efficient domino aza-MIRC (Michael Induced Ring Closure) reaction between barbiturate-derived alkenes and N-alkoxy α-haloamides has been achieved in moderate to excellent yields. This reaction proceeds smoothly under mild conditions via a domino aza-Michael addition/intramolecular SN2 sequence, providing a practical tool in the synthesis of bioactive molecules spirobarbiturate-3-pyrrolidinones.
[3 + 2]-Cycloaddition of Azaoxyallyl Cations with 1,2-Benzisoxazoles: A Rapid Entry to Oxazolines
Feng, Juan,Zhao, Ming,Lin, Xuanzi
, p. 9548 - 9560 (2019/08/26)
A novel and efficient [3 + 2] cycloaddition reaction of azaoxyallyl cations and 1,2-benzisoxazoles to give oxazoline derivatives has been developed. The transformation provides a rapid entry to functionalized oxazoline scaffolds under mild and transition-metal-free conditions, which will greatly expand the reaction types of heterocycle chemistry and pave the way for syntheses of bioactive compounds.
