6032-02-6

Upstream product

• 125133-94-0 N-methylconiine 
• 186045-61-4 (R)-2-Allyl-4-oxo-piperidine-1-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-naphthalen-2-yl-ethyl)-cyclohexyl ester 
• 186045-73-8 (R)-7-Allyl-1,4-dithia-8-aza-spiro[4.5]decane-8-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-naphthalen-2-yl-ethyl)-cyclohexyl ester 
• 186045-43-2 6-Bromo-1,4-dioxa-8-aza-spiro[4.5]decane-8-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-naphthalen-2-yl-ethyl)-cyclohexyl ester 
• 186045-52-3 4-Oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-naphthalen-2-yl-ethyl)-cyclohexyl ester 
• 226252-62-6 (R)-2-Allyl-4-oxo-piperidine-1-carboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester 
• 226252-64-8 (R)-2-Propyl-piperidine-1-carboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester 

Relevant academic research and scientific papers

Lewis acid mediated diastereoselective allylation of 3- menthyloxycarbonyl-5,6-dihydropyridin-4-ones

Sakurai allylation of menthyl enoates 5a-c afforded adducts 7a-c with low to excellent facial selectivity, depending on the Lewis acid employed to promote this 1,4-nucleophilic addition of allyltrimethylsilane. A chelated model was assumed to explain the

Lewis acid-promoted asymmetric conjugate allylation of N-acyl-2,3-dihydro-4-pyridones induced by intramolecular π interactions

Lewis acid-promoted conjugate addition reaction of an allylsilane to a series of the chiral 8-arylmenthol-derived N-acyl-2,3-dihydro-4-pyridones leads to the 2-allyl-4-piperidones with moderate to high levels of asymmetric induction, indicating π-stacking contribution to chirality control. This methodology was applied to the asymmetric synthesis of (-)-N-methylconiine. Copyright (C) 1996 Elsevier Science Ltd.