603306-52-1

Usage

Uses

Used in Organic Synthesis:
5-FLUORO-1H-INDOLE-7-CARBALDEHYDE is utilized as a key intermediate in organic synthesis for the creation of complex organic molecules. Its distinctive structure and reactivity facilitate the synthesis of a variety of compounds with potential applications in different fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-FLUORO-1H-INDOLE-7-CARBALDEHYDE serves as a crucial component in the development of new drugs and bioactive molecules. Its unique properties allow researchers to explore its potential in treating various diseases and conditions.
Used in Medicinal Chemistry:
5-FLUORO-1H-INDOLE-7-CARBALDEHYDE is employed as a building block in medicinal chemistry for the design and synthesis of novel compounds with therapeutic potential. Its biological activities make it an important candidate for further investigation and optimization to enhance its medicinal properties.
Used in Drug Discovery:
As a significant target in drug discovery, 5-FLUORO-1H-INDOLE-7-CARBALDEHYDE is explored for its potential to contribute to the development of innovative therapeutic agents. Its diverse biological activities suggest that it may play a role in addressing unmet medical needs.

InChI:InChI=1/C9H6FNO/c10-8-3-6-1-2-11-9(6)7(4-8)5-12/h1-5,11H

Upstream product

• 1826-67-1 vinyl magnesium bromide 
• 603306-58-7 2-(dibutoxymethyl)-4-fluoro-1-nitrobenzene 
• 395-81-3 5-fluoro-2-nitrobenzaldehyde 
• 1021910-38-2 7-(Dibutoxymethyl)-5-fluoro-1H-indole 
• 287121-32-8 (5-Fluoro-2-nitrophenyl)-methanol 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 

Downstream Products

• 603300-92-1 9-fluoro-3,4-dihydro-1H-[1,4]diazepino[6,7,1-hi]indole-2-carboxylic acid tert-butyl ester 
• 603288-22-8 LY2090314 

Relevant academic research and scientific papers

1,2-DIHYDRO-3H-PYRAZOL-3-ONE COMPOUNDS AND METHODS OF USING SAME

The present disclosure relates to 1,2-dihydro-3H-pyrazol-3-one compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter c

METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION

The present invention relates to compositions of minoxidil and Sonic Hedgehog (Shh) pathway activators and optionally, Wnt agonists and methods of using them to induce self-renewal of hair follicle stem cells, including inducing the hair follicle stem cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair follicle epithelial cells.

1,2-DIHYDRO-3H-PYRAZOL-3-ONE COMPOUNDS AND METHODS OF USING SAME

The present disclosure relates to l,2-dihydro-3H-pyrazol-3-one compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells (e.g. cochlear cells), including inducing the stem/progenitor cells to proliferate while maintain

1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME

The present invention relates to 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.

METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION

The present invention relates to compositions of Sonic Hedgehog (Shh) pathway activators and Wnt agonists and methods of using them to induce self-renewal of hair follicle stem cells, including inducing the hair follicle stem cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair follicle epithelial cells.

1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS

The present invention relates to 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.

POTENTIATION OF CANCER CHEMOTHERAPY

An improved method for treating gastric cancer, ovarian cancer, non-small cell lung cancer, or colorectal cancer in a patient is described, as well as pharmaceutical compositions useful for the method and a process for preparing said compositions.

HEMATOPOIETIC NEOPLASM CHEMOTHERAPY

A method and medicament for treating mixed lineage leukemia; translocated mixed lineage leukemia; translocated mixed lineage leukemia based acute myelogenous leukemia; translocated mixed lineage leukemia based acute lymphoid leukemia; a non-MLL based chronic myeloproliferative disorder, or non-MLL based acute lymphoid leukemia is provided.

BENZAZEPIN-2(1H)-ONE DERIVATIVES

Compounds of formula (I) and pharmaceutically acceptable salts thereof are agonists at the beta-2 adrenoceptor. They are useful as feed additives for livestock animals.

Substituted 3-imidazo[1,2-a]pyridin-3-yl-4-(1,2,3,4-tetrahydro-[1,4] diazepino-[6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as highly selective and potent inhibitors of glycogen synthase kinase-3

Glycogen synthase kinase-3 (GSK3) is involved in signaling from the insulin receptor. Inhibitors of GSK3 are expected to effect lowering of plasma glucose similar to insulin, making GSK3 an attractive target for the treatment of type 2 diabetes. Herein we report the discovery of a series of potent and selective GSK3 inhibitors. Compounds 7-12 show oral activity in an in vivo model of type II diabetes, and 9 and 12 have desirable PK properties.