395-81-3

Usage

Uses

Used in Pharmaceutical Industry:
5-Fluoro-2-nitrobenzaldehyde is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its chemical properties allow for the creation of diverse drug molecules with potential medicinal applications.
Used in Agrochemical Industry:
5-Fluoro-2-nitrobenzadehyde also serves as an intermediate in the production of agrochemicals, playing a crucial role in the development of pesticides and other agricultural chemicals that help protect crops and enhance agricultural productivity.
Used in Dye and Pigment Manufacturing:
5-Fluoro-2-nitrobenzaldehyde is utilized in the manufacture of dyes and pigments due to its color-producing properties, finding applications in various industries such as textiles, plastics, and printing inks.
Used in Organic Synthesis:
As a versatile building block, 5-Fluoro-2-nitrobenzaldehyde is used in organic synthesis for the production of a wide range of organic compounds through reduction, oxidation, and other chemical reactions, expanding its applications across different chemical and industrial sectors.

InChI:InChI=1/C8H7FO3/c1-12-7-4-5(9)2-3-6(7)8(10)11/h2-4H,1H3,(H,10,11)

Upstream product

• 456-48-4 3-Fluorobenzaldehyde 
• 6628-86-0 5-chloro-2-nitrobenzaldehyde 
• 446-33-3 5-Fluoro-2-nitrotoluene 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 82420-35-7 2-(bromomethyl)-4-fluoro-1-nitrobenzene 
• 1404432-54-7 C₁₀H₁₁FN₂O₂ 
• 402-64-2 1-dichloromethyl-3-fluoro-benzene 
• 352-70-5 m-Fluorotoluene 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 287121-32-8 (5-Fluoro-2-nitrophenyl)-methanol 
• 133191-70-5 5-fluoro-2-nitrobenzyl 4-methylphenyl sulfone 
• 13664-74-9 C₁₅H₁₄FN₃O₃ 

Downstream Products

• 146829-56-3 2-amino-5-fluoro benzaldehyde 
• 55149-70-7 (E)-2-Cyano-3-(5-fluoro-2-nitro-phenyl)-acrylamide 
• 720-22-9 1-<5-Fluor-2-nitrophenyl>-2-nitro-ethanol 
• 603306-58-7 2-(dibutoxymethyl)-4-fluoro-1-nitrobenzene 
• 886854-01-9 4-fluoro-2-(2,2-dibromovinyl)-1-nitrobenzene 
• 908583-97-1 (Z)-3-(5-fluoro-2-nitrophenyl)-2-(4-methoxyphenyl)acrylonitrile 
• 231296-69-8 methyl (2E)-3-(5-fluoro-2-nitrophenyl)acrylate 
• 548798-23-8 5-(dimethylamino)-2-nitrobenzaldehyde 
• 548798-25-0 2-nitro-5-phenoxybenzaldehyde 
• 942614-43-9 2-(4-(N-(2-(1H-benzimidazol-2-yl)-4-(dimethylamino)phenyl)sulfamoyl)phenoxy)acetic acid ethyl ester 
• 20423-24-9 2-amino-5-(dimethylamino)benzaldehyde 
• 942614-41-7 2-(4-(N-(4-(dimethylamino)-2-formylphenyl)sulfamoyl)phenoxy)acetic acid ethyl ester 
• 908584-17-8 3-(5-fluoro-2-nitrophenyl)-2-(4-methoxyphenyl)propionitrile 
• 863870-41-1 2-(2,2-dibromovinyl)-4-fluoro-phenylamine 

Relevant academic research and scientific papers

Mild Darzens Annulations for the Assembly of Trifluoromethylthiolated (SCF3) Aziridine and Cyclopropane Structures

We report mild new annulation approaches to trisubstituted trifluoromethylthiolated (SCF3) aziridines and cyclopropanes via Darzens inspired protocols. The products of these anionic annulations, rarely studied previously, possess attractive features rendering them valuable building blocks for synthesis platforms. In this study, trisubstituted acetophenone nucleophiles bearing SCF3 and bromine substituents in their α position were shown to undergo [2 + 1] annulations with vinyl ketones and tosyl-protected imines under mild reaction conditions.

Synthesis of Azepino[1,2-a]indole-10-amines via [6+1] Annulation of Ynenitriles with Reformatsky Reagent

Lewis acid-catalyzed [6+1] annulation reactions of 2-cyano-1-propargyl- and 2-alkynyl-1-cyanomethyl-indoles with Reformatsky reagent are described. 8-Aryl, 8-alkyl-, 8-hetaryl-, 9-aryl, and 9-alkyl-azepino[1,2-a]indole amines were obtained through a 7-endo-mode cyclization of the β-aminoacrylate intermediates. The antiproliferative activity of the azepino[1,2-a]indoles analogs against the HCT-116 cells were also examined.

Synthetic studies on indolocarbazoles: Total synthesis of staurosporine aglycon

A synthesis of staurosporine aglycon and its analogs was achieved in a 28-36% overall yield starting from 2-methylindole. The prominent key steps for the synthesis of the indolocarbazole alkaloids involved electrocyclization and nitrene insertion reactions.

A highly selective tandem cross-coupling of gem-dihaloolefins for a modular, efficient synthesis of highly functionalized indoles

(Chemical Equation Presented) A highly efficient method of indole synthesis using gem-dihalovinylaniline substrates and an organoboron reagent was developed via a Pd-catalyzed tandem intramolecular amination and an intermolecular Suzuki coupling. Aryl, alkenyl, and alkyl boron reagents are all successfully employed, making for a versatile modular approach. The reaction tolerates a variety of substitution patterns on the aniline leading to indoles with group at C2-C7. The orthogonal approach of the sequential copper- and palladium-mediated synthesis of 1,2-diarylindoles exploited the wide availability of diverse organoboron reagents.

PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDES

Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.

Substituted 3-imidazo[1,2-a]pyridin-3-yl-4-(1,2,3,4-tetrahydro-[1,4] diazepino-[6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as highly selective and potent inhibitors of glycogen synthase kinase-3

Glycogen synthase kinase-3 (GSK3) is involved in signaling from the insulin receptor. Inhibitors of GSK3 are expected to effect lowering of plasma glucose similar to insulin, making GSK3 an attractive target for the treatment of type 2 diabetes. Herein we report the discovery of a series of potent and selective GSK3 inhibitors. Compounds 7-12 show oral activity in an in vivo model of type II diabetes, and 9 and 12 have desirable PK properties.

PURINE DERIVATIVES AS KINASE INHIBITORS

The present invention provides kinase inhibitors of Formula I.

Preparation of Nitrobenzaldehydes and Nitrophenyl Ketones by Electrophilic Amination of Nitrobenzyl Aryl Sulfones

Nitrobenzyl aryl sulfones 1a-g react with 3,3-pentamethylene-oxaziridine (2) with incorporation of an NH group into the benzylic position, followed by cleavage to nitrobenzaldehydes 4a-d and nitrophenyl ketones 4e-g, respectively.

Process for the preparation of optionally substituted fluoro-nitro-benzaldehydes

Optionally substituted fluoro-nitro-benzaldehydes are prepared from optionally substituted halogeno-nitro-benzaldehydes and an alkali metal fluoride in a substantially anhydrous inert aprotic solvent, by heating to 50° to 250° C.