395-81-3

Basic information

• Product Name: 5-Fluoro-2-nitrobenzadehyde
• Synonyms: Benzaldehyde, 5-fluoro-2-nitro-;5-FLUORO-2-NITROBENZALDEHYDE;2-NITRO-5-FLUOROBENZALDEHYDE;5-Fluoro-2-nitrobenzaldehyde 98%;5-Fluoro-2-nitrobenzaldehyde98%;5-Fluoro-2-nitrobenzadehyde;4-Fluoro-2-formylnitrobenzene
• CAS NO: 395-81-3
• Molecular Formula: C₇H₄FNO₃
• Molecular Weight: 169.11
• EINECS: 206-903-8
• Product Categories: Fluorine series;Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde
• Mol File: 395-81-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 92-94°C
• Boiling Point: 153°C 23mm
• Flash Point: >110°C
• Appearance: /
• Density: 1.443 g/cm³
• Vapor Pressure: 0.00419mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility: Insoluble in water
• Sensitive: Air Sensitive
• BRN: 1869010
• CAS DataBase Reference: 5-Fluoro-2-nitrobenzadehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-2-nitrobenzadehyde(395-81-3)
• EPA Substance Registry System: 5-Fluoro-2-nitrobenzadehyde(395-81-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38
• Safety Statements: 26-36-37
• HazardClass: IRRITANT
• Hazardous Substances Data: 395-81-3(Hazardous Substances Data)

Usage

General Description

5-Fluoro-2-nitrobenzaldehyde is a chemical compound that consists of a benzene ring with a nitro group and a fluoro group attached to it. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. The compound is known for its strong odor and yellow color. It is also utilized in the manufacture of dyes, pigments, and other organic compounds. 5-Fluoro-2-nitrobenzaldehyde is a versatile building block in organic synthesis due to its ability to undergo various chemical reactions, such as reduction and oxidation, to produce a wide range of derivatives. However, it is important to handle this compound with care as it is toxic and can cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C8H7FO3/c1-12-7-4-5(9)2-3-6(7)8(10)11/h2-4H,1H3,(H,10,11)

Upstream product

• 456-48-4 3-Fluorobenzaldehyde 
• 287121-32-8 (5-Fluoro-2-nitrophenyl)-methanol 
• 6628-86-0 5-chloro-2-nitrobenzaldehyde 
• 1404432-54-7 C₁₀H₁₁FN₂O₂ 
• 446-33-3 5-Fluoro-2-nitrotoluene 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 82420-35-7 2-(bromomethyl)-4-fluoro-1-nitrobenzene 
• 402-64-2 1-dichloromethyl-3-fluoro-benzene 
• 352-70-5 m-Fluorotoluene 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 133191-70-5 5-fluoro-2-nitrobenzyl 4-methylphenyl sulfone 
• 13664-74-9 C₁₅H₁₄FN₃O₃ 

Downstream Products

• 720-22-9 1-<5-Fluor-2-nitrophenyl>-2-nitro-ethanol 
• 908583-97-1 (Z)-3-(5-fluoro-2-nitrophenyl)-2-(4-methoxyphenyl)acrylonitrile 
• 548798-23-8 5-(dimethylamino)-2-nitrobenzaldehyde 
• 548798-25-0 2-nitro-5-phenoxybenzaldehyde 
• 3094-46-0 5-Fluor-2-nitrobenzaldehyd-diacetat 
• 1214333-17-1 2-(difluoromethyl)-4-fluoro-1-nitrobenzene 
• 231296-69-8 methyl (2E)-3-(5-fluoro-2-nitrophenyl)acrylate 
• 904895-82-5 5-(4-methylpiperazin-1-yl)-2-nitrobenzaldehyde 
• 1093115-94-6 C₂₃H₁₆FN₃O₂ 
• 1093116-03-0 5-(5'-fluoro-2'-nitrophenyl)dipyrromethane 
• 848554-93-8 benzo[b]thiophen-2-yl-(5-fluoro-2-nitrophenyl)methanol 
• 1151930-57-2 C₁₂H₁₄FNO₄ 
• 113259-81-7 5-(N-morpholinyl)-2-nitrobenzaldehyde 
• 71083-14-2 6-fluoroquinoline-3-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis of Azepino[1,2-a]indole-10-amines via [6+1] Annulation of Ynenitriles with Reformatsky Reagent

Lewis acid-catalyzed [6+1] annulation reactions of 2-cyano-1-propargyl- and 2-alkynyl-1-cyanomethyl-indoles with Reformatsky reagent are described. 8-Aryl, 8-alkyl-, 8-hetaryl-, 9-aryl, and 9-alkyl-azepino[1,2-a]indole amines were obtained through a 7-endo-mode cyclization of the β-aminoacrylate intermediates. The antiproliferative activity of the azepino[1,2-a]indoles analogs against the HCT-116 cells were also examined.

Synthetic studies on indolocarbazoles: Total synthesis of staurosporine aglycon

A synthesis of staurosporine aglycon and its analogs was achieved in a 28-36% overall yield starting from 2-methylindole. The prominent key steps for the synthesis of the indolocarbazole alkaloids involved electrocyclization and nitrene insertion reactions.

PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDES

Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.