6034-54-4

Basic information

• Product Name: sodium N-acetylsulphanilate
• Synonyms: sodium N-acetylsulphanilate;4-Acetylaminobenzenesulfonic acid sodium salt;Cosaprin;N-Acetylsulfanilic acid sodium salt
• CAS NO: 6034-54-4
• Molecular Formula: C₈H₈NO₄S*Na
• Molecular Weight: 237.20819
• EINECS: 227-909-7
• Mol File: 6034-54-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.481g/cm³
• CAS DataBase Reference: sodium N-acetylsulphanilate(CAS DataBase Reference)
• NIST Chemistry Reference: sodium N-acetylsulphanilate(6034-54-4)
• EPA Substance Registry System: sodium N-acetylsulphanilate(6034-54-4)

Safety Data

• Hazardous Substances Data: 6034-54-4(Hazardous Substances Data)

Usage

General Description

Sodium N-acetylsulphanilate is a chemical compound that is often used as an intermediate in the production of various pharmaceuticals and agrochemicals. It is a sodium salt of N-acetylsulphanilate, which is derived from sulfanilic acid. sodium N-acetylsulphanilate has a wide range of applications, particularly in the pharmaceutical industry, where it is utilized in the synthesis of various drugs and medications. It is also commonly employed in the production of dyes and pigments. Sodium N-acetylsulphanilate is known for its anti-inflammatory and analgesic properties and may play a role in the treatment of certain medical conditions. Overall, this chemical compound has multiple uses and is an important intermediate in the synthesis of various valuable products.

InChI:InChI=1/C8H9NO4S.Na/c1-6(10)9-7-2-4-8(5-3-7)14(11,12)13;/h2-5H,1H3,(H,9,10)(H,11,12,13);/q;+1/p-1

Upstream product

• 108-24-7 acetic anhydride 
• 515-74-2 sodium sulfanilate 
• 54981-38-3 pyridinium 4-acetamidobenzenesulfonate 
• 64-19-7 acetic acid 

Downstream Products

• 556-08-1 p-(acetylamino)benzoic acid 
• 121-61-9 p-acetylaminobenzenesulfonamide 
• 63-74-1 sulfanilamide 

Relevant articles and documents

Beyond Basicity: Discovery of Nonbasic DENV-2 Protease Inhibitors with Potent Activity in Cell Culture

The viral serine protease NS2B-NS3 is one of the promising targets for drug discovery against dengue virus and other flaviviruses. The molecular recognition preferences of the protease favor basic, positively charged moieties as substrates and inhibitors, which leads to pharmacokinetic liabilities and off-target interactions with host proteases such as thrombin. We here present the results of efforts that were aimed specifically at the discovery and development of noncharged, small-molecular inhibitors of the flaviviral proteases. A key factor in the discovery of these compounds was a cellular reporter gene assay for the dengue protease, the DENV2proHeLa system. Extensive structure-activity relationship explorations resulted in novel benzamide derivatives with submicromolar activities in viral replication assays (EC50 0.24 μM), selectivity against off-target proteases, and negligible cytotoxicity. This structural class has increased drug-likeness compared to most of the previously published active-site-directed flaviviral protease inhibitors and includes promising candidates for further preclinical development.