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Usage

Uses

Used in Dietary Supplements:
Batatasin IV is used as a dietary supplement for its potential health benefits, including reducing oxidative stress and inflammation, and supporting immune system health.
Used in Functional Foods:
Batatasin IV is used as an ingredient in functional foods for its anti-inflammatory and antioxidant properties, which may contribute to overall health and well-being.
Used in Anticancer Research:
Batatasin IV is used as a subject of research for its potential anti-cancer properties, with the aim of developing new therapeutic approaches for cancer treatment.
Used in Nutraceutical Development:
Batatasin IV is used in the development of nutraceutical products, leveraging its health-promoting properties to create natural alternatives to synthetic medications.
Used in Sweet Potato Production:
Batatasin IV is a natural component of sweet potatoes, which can be selectively bred or enhanced to increase its concentration for improved health benefits in the food industry.

InChI:InChI=1/C15H16O3/c1-18-14-9-11(8-13(16)10-14)6-7-12-4-2-3-5-15(12)17/h2-5,8-10,16-17H,6-7H2,1H3

Upstream product

• 54922-80-4 (3-(benzyloxy)-5-methoxybenzyl)triphenylphosphonium bromide 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 
• 58026-13-4 1-(benzyloxy)-3-(bromomethyl)-5-methoxybenzene 
• 50637-28-0 (3-(benzyloxy)-5-methoxyphenyl)methanol 
• 26153-38-8 3,5-dihydroxybenzaldehyde 
• 57179-35-8 3-hydroxy-5-methoxybenzaldehyde 
• 50637-29-1 3-(benzyloxy)-5-methoxybenzaldehyde 

Relevant academic research and scientific papers

Utilizing a copper-free Sonogashira reaction in the synthesis of the leukotriene a4 hydrolase modulator batatasin IV

Batatasin IV is a dihydrostilbenoid isolated from Chinese yams which was shown to have inhibitory activities against plant growth. Later studies showed that this compound may exhibit anti-inflammatory properties by inhibiting the epoxide hydrolase activity of the leukotriene A4 hydrolase enzyme. To access the dihydrostilbenoid skeleton, a copper-free SPhos-mediated Sonogashira reaction was conceived and the substrate scope was explored. Our results indicate that the reaction can tolerate the presence of free alcohols, aldehydes, nitro groups, and anilinyl groups. However, a substituent with an acidic phenol or carboxylic acid group gave significantly lower yields. Next, a total synthesis of batatasin IV was accomplished in 16% overall yield incorporating the reported copper-free Sonogashira reaction. Finally, we show that batatasin IV inhibits the hydrolysis of alanine p-nitroanilide by leukotriene A4 hydrolase with an IC50 of 91.4 μM.

Naturally occurring Batatasins and their derivatives as α-glucosidase inhibitors

Batatasins are endogenous plant hormones found in yams and other related plant species. These plants are widely consumed as botanical dietary supplements in many parts of the world. This study investigated the inhibitory effects and mechanisms of Batatasin I, III, IV, V against α-glucosidase regarding their antidiabetic activities. The results revealed that Batatasin I, III, IV inhibited α-glucosidase in a reversible and noncompetitive manner, with IC50 values of 2.55, 1.89 and 2.52 mM respectively, while Batatasin V completely abolished its inhibitory activity even at the highest concentrations tested. Furthermore, a class of Batatasin-derived compounds with different substitution patterns was synthesized and subjected to the assay to clarify the structure-activity relationships, which suggested that the hydroxyl at the C-2′ position may play a significant role in improving the inhibitory activities. Their probable binding modes and the specificity of the binding sites were studied using molecule docking simulation. It was concluded that Batatasins, especially Batatasin III and IV, are promising α-glucosidase inhibitors, which therefore could be used as functional food to alleviate postprandial hyperglycemia and as potential candidates for the development of antidiabetic agents.