60376-77-4

Basic information

• Product Name: methyl 4-chloro-3-(dimethylaminomethyleneamino)sulfonyl-5-nitro-benzoate
• Synonyms: Methyl 4-chloro-3-{[(dimethylamino)methylene]sulfamoyl}-5-nitrobenzoate;Benzoic acid, 4-chloro-3-[[[(dimethylamino)methylene]amino]sulfonyl]-5-nitro-, methyl ester
• CAS NO: 60376-77-4
• Molecular Formula: C₁₁H₁₂ClN₃O₆S
• Molecular Weight: 349.75
• EINECS: 611-970-5
• Mol File: 60376-77-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 504.4°C at 760 mmHg
• Flash Point: 258.8°C
• Density: 1.5g/cm³
• Vapor Pressure: 2.67E-10mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: methyl 4-chloro-3-(dimethylaminomethyleneamino)sulfonyl-5-nitro-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-chloro-3-(dimethylaminomethyleneamino)sulfonyl-5-nitro-benzoate(60376-77-4)
• EPA Substance Registry System: methyl 4-chloro-3-(dimethylaminomethyleneamino)sulfonyl-5-nitro-benzoate(60376-77-4)

Safety Data

• Hazardous Substances Data: 60376-77-4(Hazardous Substances Data)

Upstream product

• 22892-96-2 4-chloro-3-nitro-5-sulfamoylbenzoic acid 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 67155-14-0 4-chloro-3-nitro-5-sulfamoyl-benzoic acid methyl ester 
• 84226-17-5 4-chloro-5-N,N-dimethylaminomethyleneamino-sulphonyl-benzoic acid methyl ester 

Downstream Products

• 22893-29-4 3-butylamino-4-chloro-5-sulfamoyl-benzoic acid 
• 1357465-06-5 3-amino-4-chloro-5-(dimethylaminomethylene-sulfamoyl)-benzoic acid methyl ester 
• 1357465-29-2 4-chloro-3-methylamino-5-(dimethylaminomethylene-sulfamoyl)-4-phenoxy-benzoic acid methyl ester 
• 1357465-07-6 4-chloro-3-dimethylamino-5-(dimethylaminomethylene-sulfamoyl)-4-phenoxy-benzoic acid methyl ester 
• 1357459-10-9 4-chloro-3-dimethylamino-5-sulfamoyl-benzoic acid 
• 1357465-08-7 3-butyrylamino-4-chloro-5-(dimethylaminomethylene-sulfamoyl)-benzoic acid methyl ester 
• 1357465-09-8 3-butylamino-4-chloro-5-(dimethylaminomethylene-sulfamoyl)-benzoic acid methyl ester 
• 66889-36-9 3-nitro-4-anilino-5-N,N-dimethylaminomethylene aminosulfonyl benzoic acid methyl ester 
• 66889-29-0 3-nitro-4-(4'-methylphenylthio)-5-N,N-dimethylaminomethylene-aminosulfonyl benzoic acid methyl ester 
• 66889-33-6 3-nitro-4-(4'-benzyloxyphenoxy)-5-N,N-dimethylaminomethylene-aminosulfonyl benzoic acid methyl ester 
• 66940-02-1 3-nitro-4-(3',4'-methylenedioxyphenoxy)-5-N,N-dimethylamino-methylene aminosulfonyl benzoic acid methyl ester 
• 66889-22-3 3-nitro-4-(4'-chlorophenoxy)-5-N,N-dimethyl-aminomethyleneaminosulfonyl-benzoic acid methyl ester 
• 66889-16-5 3-nitro-4-(4'-methoxyphenoxy)-5-N,N-dimethylaminomethyleneamino-sulfonyl benzoic acid methyl ester 
• 66889-40-5 3-nitro-4-(4'-methylanilino)-5-N,N-dimethylaminomethylene aminosulfonyl benzoic acid methyl ester 

Relevant articles and documents

ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE

The present invention provides acylsulfonamides including bumetanide derivatives and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these compounds and methods for their use. All of these analogs are particularly useful for the treatment and/or prophylaxis of conditions that involve the Na+K+Cl- co-transporter or GABAA receptor including but not limited to addictive disorders, Alzheimer's Disease, anxiety disorders, ascites, attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (autism), bipolar disorder, cancer, the improvement of cognitive function, cognitive impairment, cognitive dysfunction, depression, endothelial corneal dystrophy, edema, epilepsy, glaucoma, Huntington's Disease, inflammatory pain, insomnia, ischemia, migraine, migraine with aura, migraine without aura, neuropathic pain, nociceptive neuralgia, nociceptive pain, ocular diseases, pain, Parkinson's disease, periodic limb movement disorder (PLMD), personality disorders, postherpetic neuralgia, psychosis, restless legs syndrome (RLS), schizophrenia, seizure disorders, spasticity, tinnitus, and withdrawal syndromes.