67155-14-0

Upstream product

• 67-56-1 methanol 
• 22892-96-2 4-chloro-3-nitro-5-sulfamoylbenzoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 22893-29-4 3-butylamino-4-chloro-5-sulfamoyl-benzoic acid 
• 1357465-06-5 3-amino-4-chloro-5-(dimethylaminomethylene-sulfamoyl)-benzoic acid methyl ester 
• 1357465-29-2 4-chloro-3-methylamino-5-(dimethylaminomethylene-sulfamoyl)-4-phenoxy-benzoic acid methyl ester 
• 1357465-07-6 4-chloro-3-dimethylamino-5-(dimethylaminomethylene-sulfamoyl)-4-phenoxy-benzoic acid methyl ester 
• 1357459-10-9 4-chloro-3-dimethylamino-5-sulfamoyl-benzoic acid 
• 1357465-08-7 3-butyrylamino-4-chloro-5-(dimethylaminomethylene-sulfamoyl)-benzoic acid methyl ester 
• 1357465-09-8 3-butylamino-4-chloro-5-(dimethylaminomethylene-sulfamoyl)-benzoic acid methyl ester 
• 60376-77-4 3-nitro-4-chloro-5-N,N-dimethylaminomethyleneaminosulphonyl-benzoic acid methyl ester 

Relevant academic research and scientific papers

ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE

The present invention provides acylsulfonamides including bumetanide derivatives and compositions comprising such analogs. The present invention also provides pharmaceutical compositions containing these compounds and methods for their use. All of these analogs are particularly useful for the treatment and/or prophylaxis of conditions that involve the Na+K+Cl- co-transporter or GABAA receptor including but not limited to addictive disorders, Alzheimer's Disease, anxiety disorders, ascites, attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (autism), bipolar disorder, cancer, the improvement of cognitive function, cognitive impairment, cognitive dysfunction, depression, endothelial corneal dystrophy, edema, epilepsy, glaucoma, Huntington's Disease, inflammatory pain, insomnia, ischemia, migraine, migraine with aura, migraine without aura, neuropathic pain, nociceptive neuralgia, nociceptive pain, ocular diseases, pain, Parkinson's disease, periodic limb movement disorder (PLMD), personality disorders, postherpetic neuralgia, psychosis, restless legs syndrome (RLS), schizophrenia, seizure disorders, spasticity, tinnitus, and withdrawal syndromes.

Discovery and optimization of antibacterial AccC inhibitors

The biotin carboxylase (AccC) is part of the multi-component bacterial acetyl coenzyme-A carboxylase (ACCase) and is essential for pathogen survival. We describe herein the affinity optimization of an initial hit to give 2-(2-chlorobenzylamino)-1-(cyclohe