60376-97-8

Usage

Uses

Used in Pharmaceutical Research:
CHEMBRDG-BB 4022320 is used as a research compound for investigating its anti-inflammatory and antinociceptive properties. Its potential to alleviate pain and reduce inflammation makes it a valuable asset in the development of new medications for pain and inflammation-related conditions.
Used in Drug Development:
In the field of drug development, CHEMBRDG-BB 4022320 is utilized as a starting point for creating new therapeutic agents. Its unique chemical structure and biological activity can be further optimized to enhance its efficacy and safety, leading to the creation of novel drugs for treating various medical conditions.
Used in Medicinal Research:
CHEMBRDG-BB 4022320 serves as a key component in medicinal research, where scientists explore its potential applications in treating specific diseases and disorders. Its anti-inflammatory and antinociceptive properties make it a candidate for studying its effects on a wide range of conditions, from chronic pain to inflammatory diseases.
Used in Treatment of Pain and Inflammation-Related Conditions:
Although further research is needed, CHEMBRDG-BB 4022320 has the potential to be used as a therapeutic agent for the treatment or management of pain and inflammation-related conditions. Its ability to reduce inflammation and alleviate pain could provide relief to patients suffering from various ailments, improving their quality of life and overall well-being.

InChI:InChI=1/C10H14BrN/c1-8(2)12-7-9-3-5-10(11)6-4-9/h3-6,8,12H,7H2,1-2H3

Upstream product

• 98816-61-6 N-(4-bromobenzyl)-N-isopropylpropan-2-amine 
• 336182-29-7 4-bromo-N-isopropyl-benzamide 
• 75-31-0 isopropylamine 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 589-17-3 p-bromobenzyl chloride 
• 586-75-4 4-chlorobenzoyl chloride 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 55246-38-3 C₁₁H₁₃BrClNO 
• 60376-93-4 N-(4-bromobenzyl)-N-isopropyl-N'-phenylthiourea 

Relevant academic research and scientific papers

Hydrogenation of Secondary Amides using Phosphane Oxide and Frustrated Lewis Pair Catalysis

The metal-free catalytic hydrogenation of secondary carboxylic acid amides is developed. The reduction is realized by two new catalytic reactions. First, the amide is converted into the imidoyl chloride by triphosgene (CO(OCCl3)2) using novel phosphorus(V) catalysts. Second, the in situ generated imidoyl chlorides are hydrogenated in high yields by an FLP-catalyst. Mechanistic and quantum mechanical calculations support an autoinduced catalytic cycle for the hydrogenation with chloride acting as unusual Lewis base for FLP-mediated H2-activation.

SMALL-MOLECULE INHIBITORS FOR THE Β-CATENIN/B-CELL LYMPHOMA 9 PROTEIN?PROTEIN INTERACTION

Disclosed are inhibitors for the β-catenin/B-cell lymphoma 9 interaction. The inhibitors are selective for β-catenin/B-cell lymphoma 9 over β-catenin/ E-cadherin PPI interaction. Methods of using the disclosed compounds to treat cancer are also disclosed.

Design, synthesis and biological evaluation of triaryl compounds as novel 20S proteasome inhibitors

Thirty novel triaryl compounds were designed and synthesized based on the known proteasome inhibitor PI-1840. Most of them showed significant inhibition against the β5c subunit of human 20S proteasome, and five of them exhibited IC50 values at the sub-micromolar level, which were comparable to or even more potent than PI-1840. The most active two (1c and 1d) showed IC50 values of 0.12 and 0.18 μM against the β5c subunit, respectively, while they displayed no obvious inhibition against the β2c, β1c and β5i subunits. Molecular docking provided informative clues for the subunit selectivity. The potent and subunit selective proteasome inhibitors identified herein represent new chemical templates for further molecular optimization.

Mild Metal-Free Hydrosilylation of Secondary Amides to Amines

The combination of amide activation by Tf2O with B(C6F5)3-catalyzed hydrosilylation with TMDS constitutes a method for the one-pot reduction of secondary amides to amines under mild conditions. The method displays a broad applicability for the reduction of many types of substrates, and shows good compatibility and excellent chemoselectivity for many sensitive functional groups. Reductions of a multifunctionalized α,β-unsaturated amide obtained from another synthetic methodology, and a C-H functionalization product produced the corresponding amines in good to excellent yield. Chemoselective reduction of enantiomeric pure (ee >99%) tetrahydro-5-oxo-2-furaneamides yielded 5-(aminomethyl)dihydrofuran-2(3H)-ones in a racemization-free manner. The latter were converted in one pot to N-protected 5-hydroxypiperidin-2-ones, which are building blocks for the synthesis of many natural products. Further elaboration of an intermediate led to a concise four-step synthesis of -epi-pseudoconhydrine.

Aqueous Suzuki Coupling Reactions of Basic Nitrogen-Containing Substrates in the Absence of Added Base and Ligand: Observation of High Yields under Acidic Conditions

A series of aqueous heterogeneous Suzuki coupling reactions of substrates containing basic nitrogen centers with phenylboronic acid in the absence of added base and ligand is presented. High yields of products were obtained by employing aryl bromides containing aliphatic 1°, 2°, and 3° amine substituents, and good to high yields were obtained by employing a variety of substituted bromopyridines. In the former series, the pH of the aqueous phase changed from basic to acidic during the course of the reaction, while in the latter series the aqueous phase was on the acidic side of the pH scale throughout the entire course of reaction. A mechanistic interpretation for these observations, which generally preserves the oxo palladium catalytic cycle widely accepted in the literature, is presented.

Transformation of N,N-diisopropylarylmethylamines into N-isopropylarylmethylamines with molecular iodine

N,N-Diisopropylarylmethylamines were smoothly converted into the corresponding N-isopropylarylmethylamines by the reaction with molecular iodine in the presence of Na2CO3 in chloroform at 60 °C. Other related tertiary amines were also transformed into the corresponding secondary amines by the reaction with molecular iodine under the same reaction conditions.