6038-59-1

Basic information

• Product Name: 3'-O-METHYLURIDINE
• Synonyms: 3'-O-METHYLURIDINE
• CAS NO: 6038-59-1
• Molecular Formula: C₁₀H₁₄N₂O₆
• Molecular Weight: 258.23
• Product Categories: Biochemicals and Reagents;Nucleoside Analogs;Nucleosides, Nucleotides, Oligonucleotides
• Mol File: 6038-59-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: 3'-O-METHYLURIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-O-METHYLURIDINE(6038-59-1)
• EPA Substance Registry System: 3'-O-METHYLURIDINE(6038-59-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 6038-59-1(Hazardous Substances Data)

Usage

General Description

3'-O-Methyluridine is a modified form of uridine, a nucleoside (building block) found in RNA. This modification involves the addition of a methyl group to the 3' carbon of the ribose sugar in the uridine molecule. 3'-O-Methyluridine has been found to play a role in modulating RNA structure and function. It has also been investigated for its potential therapeutic applications, particularly in the field of antiviral drug development. The modification of uridine to 3'-O-Methyluridine can affect the stability and activity of RNA, making it a molecule of interest for researchers studying the molecular mechanisms of RNA and its potential use in biomedical applications.

Upstream product

• 1213263-37-6 C₂₅H₂₈N₂O₇ 
• 174020-29-2 3'-O-methyl-5'-O-(monomethoxytrityl)uridine 
• 186581-53-3 diazomethane 
• 58-96-8 uridine 

Relevant articles and documents

A reliable Pd-mediated hydrogenolytic deprotection of BOM group of uridine ureido nitrogen

The benzyloxymethyl (BOM) group has been utilized widely in syntheses of a variety of natural and non-natural products. The BOM group is also one of few choices to protect uridine ureido nitrogen. However, hydrogenolytic cleavage of the BOM group of uridine derivatives has been unreliably performed via heterogeneous conditions using Pd catalysts. One of the undesirable by-products formed by Pd-mediated hydrogenation conditions is the over-reduced product in which the C5-C6 double bond of the uracil moiety was saturated. To date, we have generated a wide range of uridine-containing antibacterial agents, where the BOM group has been utilized in their syntheses. In screening of deprotection conditions of the BOM group of uridine ureido nitrogen under Pd-mediated hydrogenation conditions, we realized that the addition of water to the iPrOH-based hydrogenation conditions can suppress the formation of over-reduced uridine derivatives and the addition of HCO2H (0.5%) dramatically improve the reaction rate. An optimized hydrogenation condition described here can be applicable to the BOM-deprotections of a wide range of uridine derivatives.

5'-O-Trityl Group Promoted Directive Effect in the Preparation of 2'-O-Methylribonucleosides

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Preparation of O'-alkyl derivatives of cytosine and uracil nucleosides.

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