603959-54-2 Usage
Uses
Used in Pharmaceutical Research:
(-)-(S)-ethyl 3-hydroxy-3-(thiophen-2-yl)propanoate is used as a chiral building block for the development of pharmaceuticals, agrochemicals, and other fine chemicals. Its unique reactivity and properties, along with its chiral nature, make it valuable in creating new and effective drug molecules.
Used in Organic Synthesis:
(-)-(S)-ethyl 3-hydroxy-3-(thiophen-2-yl)propanoate is used as a resolving agent or chiral auxiliary in asymmetric synthesis. Its ability to introduce chirality into molecules makes it a versatile chemical for creating enantiomerically pure compounds, which are essential in various chemical reactions and applications.
Used in Drug Development:
(-)-(S)-ethyl 3-hydroxy-3-(thiophen-2-yl)propanoate is used in the development of new drugs and pharmaceuticals. Its unique properties and reactivity, along with its chiral nature, make it a valuable component in the creation of innovative and effective drug molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 603959-54-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,0,3,9,5 and 9 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 603959-54:
(8*6)+(7*0)+(6*3)+(5*9)+(4*5)+(3*9)+(2*5)+(1*4)=172
172 % 10 = 2
So 603959-54-2 is a valid CAS Registry Number.
603959-54-2Relevant academic research and scientific papers
Chen, Xiang,Liu, Zhi-Qiang,Lin, Chao-Ping,Zheng, Yu-Guo
, p. 82 - 89 (2016)
A chemoenzymatic strategy was developed for (S)-duloxetine production employing carbonyl reductases from newly isolated Rhodosporidium toruloides into the enantiodetermining step. Amongst the ten most permissive enzymes identified, cloned, and overexpressed in Escherichia coli, RtSCR9 exhibited excellent activity and enantioselectivity. Using co-expressed E. coli harboring both RtSCR9 and glucose dehydrogenase, (S)-3-(dimethylamino)-1-(2-thienyl)-1-propanol 3a was fabricated with so far the highest substrate loading (1000 mM) in a space-time yield per gram of biomass (DCW) of 22.9 mmol L-1 h-1 g DCW-1 at a 200-g scale. The subsequent synthetic steps from RtSCR9-catalyzed (S)-3a were further performed, affording (S)-duloxetine with 60.2% overall yield from 2-acethylthiophene in >98.5% ee.
